Integrative Omics Analysis of the Effect of Bacteria on the Resistance of Entamoeba histolytica to Oxidative Stress

  • Yana Shaulov
  • Serge AnkriEmail author
Conference paper


Entamoeba histolytica, the etiological agent of amebiasis interacts with and feeds on the gut microbiota. Several studies have emphasized the close relationship between E. histolytica and the bacteria and its impact on the parasite’s pathogenesis. In this work we present an integrated omics analysis of the effect of E. coli and other bacteria on the resistance of E. histolytica to oxidative stress.


Entamoeba Enterobacterium Stress Intestinal flora Malate dehydrogenase Oxaloacetate Leucine rich repeat proteins 



Glyceraldehyde-3-phosphate dehydrogenase putative


Heat killed bacteria


Heat killed bacteria exposed to oxidative stress


Live bacteria


Leucine rich repeat proteins


Malate dehydrogenase


Oxidative stress


Oxidized proteins


Resin assisted capture of oxidized proteins


Nitrosative stress


Acknowledgements and Funding

We would like to acknowledge the assistance of Ms. Shruti Nagaraja in the preparation of Fig. 3.1.

This study was supported by grants from the Israel Science Foundation (260/16), the US-Israel Binational Science Foundation (2015211), the Niedersachsen-Israel ZN3454 program and the European ERA-NET Infect-ERA program AMOEBAC (Israel Ministry of Health Grant 031L000).


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of MedicineTechnionHaifaIsrael

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