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Acute Kidney Injury in Tetanus

  • Juliana Gomes Ramalho de Oliveira
  • Geraldo Bezerra da Silva JuniorEmail author
  • Guilherme Alves de Lima Henn
  • Elizabeth De Francesco Daher
Chapter
  • 29 Downloads

Abstract

Tetanus is an acute infectious disease caused by neurotoxins produced by Clostridium tetani, an anaerobic sporulated gram-positive bacillus. The infection occurs through superficial or deep wounds used as spore entry ports for contact with the continuity solution in the skin and mucosa. The action of Clostridium tetani in the body occurs through the release of exotoxins such as tetanospasmin, also known as tetanus toxin, which, due to its action of inhibiting neurotransmitter release, is responsible for the clinical manifestations of the infection, according to the class and the location of affected cells. The disease progresses in the cephalo-caudal direction, with initial involvement of the head and neck muscles, until symptoms are completely widespread. Hypertonia of the facial muscles gives the patient expressions that are characteristic of the disease, also known as tetanus face. With the evolution of the infection, the involvement of the thoracic, abdominal, and diaphragmatic muscles can lead to asphyxia, with cyanosis and respiratory failure. Acute kidney injury (AKI) in tetanus infection is common, occurs early and is associated with increased mortality, but its pathophysiology is not yet completely understood. Some factors have been studied as possible causes of AKI, such as autonomic dysfunction, rhabdomyolysis, use of nephrotoxic medications, sepsis, mechanical ventilation complications, dehydration, and changes in renal blood circulation, secondary to catecholamine surges.

Keywords

Tetanus Clostridium Clostridium tetani Acute kidney injury Rhabdomyolysis 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Juliana Gomes Ramalho de Oliveira
    • 1
  • Geraldo Bezerra da Silva Junior
    • 2
    Email author
  • Guilherme Alves de Lima Henn
    • 3
  • Elizabeth De Francesco Daher
    • 4
  1. 1.Post-Graduation Program in Public HealthUniversity of FortalezaFortalezaBrazil
  2. 2.Post-Graduation Programs in Public Health and Medical Sciences, School of MedicineUniversity of FortalezaFortalezaBrazil
  3. 3.Department of Community HealthFederal University of CearaFortalezaBrazil
  4. 4.Post-Graduation Program in Medical Sciences, School of MedicineFederal University of CearaFortalezaBrazil

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