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Gene Regulatory Network Construction Parallel Technique Based on Network Component Analysis

  • Dina ElsayadEmail author
  • Safwat Hamad
  • Howida A. Shedeed
  • Mohamed F. Tolba
Conference paper
  • 44 Downloads
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 1153)

Abstract

Construction of a gene regulatory network is a vital process for understanding the gene functions and gene influences on the other genes. Furthermore, gene regulatory network analysis is a promising method for demonstrating the topological order of genes interactions. One technique for constructing a gene regulatory network is FastNCA that is based on network component analysis methodology. Although FastNCA is widely used to construct the gene regulatory network of cancer diseases associated genes, it is a time-consuming and computational intensive technique. As a result, this paper presents an enhanced parallel implementation of FastNCA that uses distributed parallelism methodology to enhance the performance of FastNCA. Different gene datasets are used to evaluate the performance of the proposed algorithm. The experimental results demonstrate that the proposed algorithm outperforms FastNCA. Where the achieved speedup is up to 250 on 256 processing nodes.

Keywords

Network Component Analysis Parallel computing Regulatory network Genes High-Performance Computing 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Dina Elsayad
    • 1
    Email author
  • Safwat Hamad
    • 1
  • Howida A. Shedeed
    • 1
  • Mohamed F. Tolba
    • 1
  1. 1.Faculty of Computer and Information SciencesAin Shams UniversityCairoEgypt

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