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Relation Between PTH and Biochemical Markers of MBD

  • Pablo A. Ureña-TorresEmail author
  • Jordi Bover
  • Martine Cohen-Solal
Chapter
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Abstract

Chronic kidney disease (CKD) is often associated with bone disorders including secondary hyperparathyroidism, aluminum-related low turnover bone disease, osteomalacia, adynamic osteopathy, osteoporosis, and skeletal ß2-microglobulin amyloid deposits. In spite of the enormous progress made during the last few years in the search of non-invasive methods to assess bone metabolism, still the distinction between high and low turnover bone diseases in these patients, frequently requires invasive and/or costly procedures such as bone biopsy after double tetracycline labeling, scintigraphic-scan studies, computed tomography, densitometry, and kinetic studies with radiolabeled molecules. This review assesses the relation of parathyroid hormone (PTH) with old and the most recent biomarkers of bone metabolism in the diagnosis and monitoring of CKD bone disease. It evaluates the metabolism of collagen-related proteins such as type I collagen C- and N-terminal pro-peptides (P1NP and PICP), and collagen crosslinked molecules in the assessment of ROD, as well as the non-collagenous proteins such as bone-specific alkaline phosphatase (BSAP) and tartrate-resistant acid phosphatase (TRAP5b). New molecules such as fibroblast growth factor 23 (FGF23), klotho, sclerostin and Dkk1 could also emerge as interesting biomarkers of bone metabolism. The future use of these markers, individually or in combination with PTH will undoubtedly improve the diagnosis and the treatment of the complex ROD.

Keywords

Alkaline phosphatases Bone remodeling Calcium Phosphate Magnesium Vitamin D Bone mineral density Fracture 

Notes

Disclosure

PAUT has received consulting fee from Amgen, Astellas, Abbvie, AstraZeneca, GSK, Hemotech, Fresenius and Vifor Pharma FMC. JB has not received consulting fees related to this work.

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Pablo A. Ureña-Torres
    • 1
    Email author
  • Jordi Bover
    • 2
  • Martine Cohen-Solal
    • 3
  1. 1.AURA Nord Saint Ouen, Department of Dialysis and Department of Renal Physiology, Necker HospitalUniversity of Paris DescartesParisFrance
  2. 2.Fundació Puigvert, Department of NephrologyBarcelonaSpain
  3. 3.INSERM U1132 & USPC Paris-Diderot; Department of Rheumatology; Hôpital LariboisièreParisFrance

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