Role of Sedation and Analgesia During Noninvasive Ventilation

  • Subrata Kumar Singha
  • Habib Md Reazaul Karim
  • Camilla Calandra
  • Savino Spadaro


Noninvasive ventilation (NIV) is increasingly used in acute respiratory failure in order to avoid complications related to invasive mechanical ventilation. Patient’s compliance is essential to its success, therefore sedative and/or analgesic drugs could be potentially used to reduce discomfort and risk of NIV failure in selected patients. Although sedation and analgesia have a potentially beneficial and even deleterious role, guidelines to specifically address this issue and recommend for or against is relatively missing. Even in the most recent clinical practice guidelines by ERS/ATS for the use of NIV for ARF published in 2017, guidance on sedation and analgesia is missing. Electronic databases (Google Scholar, PubMed, and Cochrane Library) from 2017 to 2019 were searched to find out the recent literature related to sedation in noninvasive ventilation. In this chapter, a brief review of the literature and analysis of the studies related to sedation and analgesia were also done.


Noninvasive ventilation Sedation Analgesia Failure Discomfort 



Acute cardiogenic pulmonary edema


Acute respiratory failure


Chronic obstructive pulmonary disease


Noninvasive ventilation


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Subrata Kumar Singha
    • 1
  • Habib Md Reazaul Karim
    • 1
  • Camilla Calandra
    • 2
  • Savino Spadaro
    • 2
  1. 1.Department of Anaesthesiology and Critical CareAll India Institute of Medical SciencesRaipurIndia
  2. 2.Section of Anesthesiology and Intensive Care, Department of Morphology, Surgery and Experimental MedicineUniversity of FerraraFerraraItaly

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