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The IL-17/Th17 Axis as a Therapeutic Target in Periodontitis

  • Nicolas DutzanEmail author
  • Loreto Abusleme
  • Niki Moutsopoulos
Chapter
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Abstract

The Th17/IL-17 axis has been implicated in the pathogenesis of several inflammatory and autoimmune diseases including psoriasis, rheumatoid arthritis, and periodontitis. Indeed, in periodontitis, recent studies have further highlighted the role of the Th17/IL-17 axis in mediating immunopathology underscoring this pathway as a plausible therapeutic target for this disease. In this chapter, we focused not only on the role of IL-17A during immunopathology but also on its protective roles at mucosal barrier sites. We discussed the role of Th17 cells and IL-17A in oral mucosa homeostasis, their regulation and role in periodontal immunopathology. Finally, we reviewed the currently used agents for the management of Th17/IL-17 mediated diseases and commented on their possible use in the treatment of periodontitis.

Keywords

Th17 IL-17 Periodontitis Immunopathology Inflammation Therapy Target Oral Mucosa Gingiva 

Notes

Acknowledgments

This work was partly funded by the Chilean government through FONDECYT # 11180389 (to N.D) and FONDECYT # 11180505 (to L.A).

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Nicolas Dutzan
    • 1
    Email author
  • Loreto Abusleme
    • 1
  • Niki Moutsopoulos
    • 2
  1. 1.Laboratory of Oral Microbiology and Laboratory for Craniofacial Translational ResearchFaculty of Dentistry, University of ChileSantiagoChile
  2. 2.Oral Immunity and Inflammation UnitNIDCR, NIHBethesdaUSA

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