Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation

  • Anthony J. Hickey
  • Hugh D. C. Smyth
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)


Pharmaceutical systems and products almost always include solid-state ingredients either during manufacture or as the dosage form itself. Thus preformulation and formulation of drug products is often critically dependent on the characterization and understanding of these physicochemical properties. Despite their seemingly simplicity, attributes like dissolution, particle shape, and powder flow can be exceedingly complex and often require nonlinear approaches for modeling, prediction, and analysis. This section provides examples both from static and dynamic processes encountered in pharmaceutical preformulation/formulation development.


Physicochemical properties Dynamical systems Solubility Dissolution Fractal Monte Carlo Powder flow Powder mixing 


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© American Association of Pharmaceutical Scientists 2020

Authors and Affiliations

  • Anthony J. Hickey
    • 1
  • Hugh D. C. Smyth
    • 2
  1. 1.RTI InternationalResearch Triangle ParkUSA
  2. 2.College of PharmacyThe University of Texas at AustinAustinUSA

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