IGrC: Cognitive and Motor Changes During Symptoms Development in Parkinson’s Disease Patients

  • Andrzej W. PrzybyszewskiEmail author
  • Jerzy Paweł Nowacki
  • Aldona Drabik
  • Stanislaw Szlufik
  • Dariusz M. Koziorowski
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 12034)


Cognitive symptoms are characteristic for neurodegenerative disease: there are dominating in the Alzheimer’s, but secondary in Parkinson’s disease (PD). However, in PD motor symptoms (MS) are dominating and their characteristic helps neurologist to recognize the disease. There are a large number of data mining publications that analyzed MS in PD. Present study is related to the question if development of cognitive symptoms is related to motor symptoms or if they are two independent processes? We have responded to this problem with help of IGrC (intelligent granular computing) approach. We have put together eye movement, neurological and neuropsychological tests. Our study was dedicated to 47 Parkinson’s disease patients in two sessions: S#1 - without medications (MedOFF) and S#2 after taking medications (MedON). There were two groups of patients: Gr1 (23 patients) less advanced and Gr2 more advanced PD. We have measured Gr1 in three visits every 6 months: Gr1VIS1, Gr1VIS2, Gr1VIS3. Gr2 (24 patients) has only one visit (no visit number). With rough set theory (RST) that belongs to IGrC we have found from Gr2 three different sets of rules: a) general rules (GRUL) determined by all attributes; b) motor related rules (MRUL) – motor attributes; c) cognitive rules (CRUL) determined by cognitive attributes. By applying these different sets of rules to different Gr1 visits we have found different set of symptoms developments. With GRUL we have found for Gr1VIS1 accuracy = 0.682, for Gr1VIS2 acc. = 0.857, for Gr1VIS3 acc. = 0.875. With MRUL we have found for Gr1VIS1 acc. = 0.80, for Gr1VIS2 acc. = 0.933, for Gr1VIS3 acc. = 1.0. With CRUL we have found for Gr1VIS1 acc. = 0.50, for Gr1VIS2 acc. = 0.60, for Gr1VIS3 acc. = 0.636. Cognitive changes are independent from the motor symptoms development.


Neurodegeneration Rough set theory Intelligent granular computing 


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Authors and Affiliations

  1. 1.Polish-Japanese Academy of Information TechnologyWarsawPoland
  2. 2.Department of Neurology, Faculty of Health ScienceMedical University of WarsawWarsawPoland

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