Optimal Control Problem of a Metronomic Chemotherapy

  • Dieter Grass
  • Valeriya LykinaEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11958)


In this paper we consider a metronomic chemotherapy model which is optimally controlled over the expected future lifetime of the particular patient. Under certain assumptions concerning the distribution of the future lifetime of the patient, it can be easily transformed to a purely deterministic optimal control problem with infinite horizon. To solve the latter the open source software package OCMat was used. Solutions to optimal control problems with \(L_2-\) and regularized \(L_1-\)objective functionals have been compared.


Infinite horizon optimal control Metronomic chemotherapy Numerical analysis 


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Authors and Affiliations

  1. 1.Research Unit Operations Research and Control of Systems (ORCOS)Vienna University of TechnologyViennaAustria
  2. 2.Institute for Mathematics, Department of OptimizationBrandenburg University of Technology at Cottbus-SenftenbergCottbusGermany

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