Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction

  • Shinichi SomeyaEmail author
  • Christina Rothenberger
  • Mi-Jung Kim


Hearing loss is the third most prevalent chronic health condition and can lead to social isolation and major communication difficulties. The World Health Organization (WHO) estimates that one-third of persons over 65 years have disabling hearing loss. Currently, 466 million people in the world suffer hearing impairment. WHO projects that it could rise to 630 million by 2030 and over 900 million in 2050. Approximately 48 million Americans have unilateral or bilateral hearing loss, and 45% of adults aged 60–69 have hearing loss. It is well documented that reducing calorie intake or calorie restriction (CR) extends life span in diverse species and delays the onset of a variety of age-related diseases, including hypertension, diabetes, cancer, and cardiovascular disease in laboratory animals. Increasing evidence also indicates that CR has beneficial effects on auditory function in rodents and nonhuman primates. This chapter reviews the current literature on interventions for age-related hearing loss (AHL), particularly focusing on a lifestyle-based intervention, CR, and what has been learned about the mechanisms underlying the beneficial effects of CR on auditory function in laboratory animals and humans.


Calorie restriction Oxidative stress Mitochondrial dysfunction Obesity Aging 





Hydroxyl radical


Auditory brainstem response


Age-related hearing loss



Complex I

NADH dehydrogenase

Complex III

Ubiquinone–cytochrome c reductase


Calorie restriction


Glutathione peroxidase 1


Reduced glutathione


Glutathione reductase


Oxidized glutathione


Glutathione S-transferase mu 1


Glutathione S-transferase pi 1


Glutathione S-transferase theta 1


Hydrogen peroxide


Inner hair cells


Mitochondrial DNA


National Institute on Aging


Noise-induced hearing loss


Outer hair cells


Peroxiredoxin 3


Reactive oxygen species


Spiral ganglion neuron


Superoxide dismutase 1


Superoxide dismutase 2


Stria vascularis


Thioredoxin reductase


University of Wisconsin–Madison


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Shinichi Someya
    • 1
    Email author
  • Christina Rothenberger
    • 1
  • Mi-Jung Kim
    • 1
  1. 1.Department of Aging and Geriatric ResearchUniversity of FloridaGainesvilleUSA

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