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The Electrical Model of Multicellular Systems Based on Circuit Simulation Techniques

  • R. R. Aliev
  • M. M. GouraryEmail author
  • S. G. Rusakov
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 1126)

Abstract

The paper presents the model for the evaluation of the electric field in the cellular tissue. The model in the form of an electrical network is obtained by modifying the known transport lattice model. The network parameters are defined by applying the finite volume method to the Maxwell equations for an electric field in a homogeneous medium. It is shown that the main limitation of the known form of transport lattice method is the stepped approximation of the cell surface. To eliminate the error a new approach based on projecting the steps on the membrane surface is developed. Numerical experiments by the circuit simulator confirmed the error decrease due to the proposed approach.

Keywords

Cellular tissue Cell membrane Finite Volume Method Transfer function Circuit simulation Electric network 

Notes

Acknowledgment

The study was financially supported by the Russian Foundation for Basic Research (project no. 19-29-03012).

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Copyright information

© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Theoretical and Experimental Biophysics of Russian Academy of SciencesMoscowRussia
  2. 2.Moscow Institute of Physics and TechnologyDolgoprudnyRussia
  3. 3.Institute for Design Problems in Microelectronics of Russian Academy of Sciences, (IPPM RAS)MoscowRussia

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