Basic Concepts of Vaccine Immunology
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The first two chapters of this book are intended to provide the reader with the necessary background knowledge of the fundamentals of vaccination. This chapter opens with an overview of the major infectious microorganisms. Next, the working of the immune system is explained, how it can ward off microorganisms it has encountered before. The primary defence mechanism of microorganisms—antigenic variation—is examined. An overview of the several types of vaccines for viruses and bacteria, from the first-generation live attenuated vaccines to third-generation vaccines such as recombinant vector vaccines, DNA vaccines and virus-like particles vaccines is given.