Rare Preputial Anomalies

  • Mohamed A. Baky Fahmy


There are more than 30 articles indexed till March 2019 in PubMed and Google scholar for rare preputial anomalies and diseases. As the prepuce was sacrificed globally along man history, and its fate is still a removal in many countries; so there is no proper chances to record in details and to report all its anomalies, specially the rare ones. Prepuce may had many rare developmental congenital anomalies, some of them are described separately in chapters; like aposthia, and prepuce may be also affected along other acquired diseases either infectious, traumatic or systemic. Rare diseases in general may not be concerned by some physicians, but they are disquieting to families and patients, and lead to a great apprehension. We will highlight some of these rare anomalies, which were not reported before, and other cases which just reported as a case reports or case series. These condition may be congenital either as an isolated anomaly or associated with other syndromes and seen immediately after delivery, others are acquired and detected late at adulthood.
  • Rare non reported anomalies of the prepuce

  • Preputial cutaneous horn

  • Pilonidal sinus and cyst

  • Penile Phlebectasia

  • Preputial Crohn’s disease

  • Preputial Histoplasma

  • Preputial Porokeratosis

  • Localized amyloidosis

  • Pyoderma gangrenosum


Notched prepuce Preputial angulation Median raphe adhesion Angiokeratoma Crohn’s disease Porokeratosis preputial perforation Pyoderma gangrenosum Preputial Crohn’s disease Histoplasmic Phimosis 



Penile extra-gastrointestinal Crohn’s disease


Pyoderma gangrenosum


  1. 1.
    Sarkis PE, Muthurajan S. Incidence and predictive factors of isolated neonatal penile glanular torsion. J Pediatr Urol. 2007;3:495–9.CrossRefGoogle Scholar
  2. 2.
    Eroglu E, Gundogdu G. Isolated penile torsion in newborns. Can Urol Assoc J. 2015;9(11–12):E805–7. Scholar
  3. 3.
    Baky Fahmy M. The spectrum of genital median raphe anomalies among infants undergoing ritual circumcision. J Pediatr Urol. 2013;9(6):872–7. Scholar
  4. 4.
    Sumit Sethi S, et al. Herpetic perforation of prepuce. Indian J Dermatol Venereol Leprol. 2018;84:65. Scholar
  5. 5.
    Bondeson J. Everard home, john hunter, and cutaneous horns: a historical review. Am J Dermatopathol. 2001;23:362–9.CrossRefGoogle Scholar
  6. 6.
    Agarwala MK, Mukhopadhyay S, Sekhar MR, Menon A, Dincy Peter CV. Solitary angiokeratoma presenting as cutaneous horn over the prepuce: a rare appearance. Indian J Dermatol. 2016;61:236.CrossRefGoogle Scholar
  7. 7.
    Barolia DK, Sethi D, Sethi A, Ram J, Meena S, Rachhoya P. Penile cutaneous horn—a rare case. Int J Med Res Rev. 2015;3:1102–4.CrossRefGoogle Scholar
  8. 8.
    Yu RC, Pryce DW, Macfarlane AW, Stewart TW. A histopathological study of 643 cutaneous horns. Br J Dermatol. 1991;124:449–52.CrossRefGoogle Scholar
  9. 9.
    Mantese SA, Diogo PM, Rocha A, Berbert AL, Ferreira AK, Ferreira TC. Cutaneous horn: a retrospective histopathological study of 222 cases. An Bras Dermatol. 2010;85:157–63.CrossRefGoogle Scholar
  10. 10.
    Randhawa K, Thomas S, Keanie J, Shukla CJ. Pilonidal sinus of the penis: merits of preoperative radiological diagnosis. J Clin Urol. 2019:205141581984015.
  11. 11.
    Kulaylat MN, Gong M, Doerr RJ. Multimodality treatment of squamous cell carcinoma complicating pilonidal disease. Am Surg. 1996;62:922–9.PubMedGoogle Scholar
  12. 12.
    Ercil H, Alma E, Eflatun Deniz M, et al. Recurrent pilonidal sinus cyst on penis. Arch Iran Med. 2018;21:131–3.PubMedGoogle Scholar
  13. 13.
    Edington GH. Some malformations of the penis. Br Med J. 1907;2(2438):725–9. JSTOR, Scholar
  14. 14.
    Balato N, Montesano N. Acquired phlebectasia of the glans penis. J Am Acad Dermatol. 1985;13:824–6.CrossRefGoogle Scholar
  15. 15.
    Bhoyrul B, Hilmy M, Lyon C. Crohn’s disease of the penis and scrotum: a prospective study. Eur J Gastroenterol Hepatol. 2018;30:1528–9.CrossRefGoogle Scholar
  16. 16.
    Casson DH, Eltumi M, Tomlin S, et al. Topical tacrolimus may be effective in the treatment of oral and perineal Crohn’s disease. Gut. 2000;47:436–40.CrossRefGoogle Scholar
  17. 17.
    Tally MR, Orenstein SR, Cohen BA. Crohn’s disease of the vulva in an 8-year-old girl. Pediatr Dermatol. 1988;5:103–6.CrossRefGoogle Scholar
  18. 18.
    Paixao M, Miot HA, Avancini J, Belda Junior W. Primary cutaneous histoplasmosis developed in the penis of an immunocompetent patient. An Bras Dermatol. 2015;90:255–7.CrossRefGoogle Scholar
  19. 19.
    Liang C, Batra P, Patel R, Kamino H. Genital porokeratosis. Dermatol Online J. 2009;15:23.PubMedGoogle Scholar
  20. 20.
    Ritter M, Nawab RA, Tannenbaum M, Hakky SI, Morgan MB. Localized amyloidosis of the glans penis: a case report and literature review. J Cutan Pathol. 2003;30:37–40.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Mohamed A. Baky Fahmy
    • 1
  1. 1.Pediatric SurgeryAl Azher UniversityCairoEgypt

Personalised recommendations