Consequences of Oxidative Stress and ROS-Mediated Pathways Cellular Signaling Stress Response

Part of the Nanomedicine and Nanotoxicology book series (NANOMED)


There are numerous extra- and intracellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause damage to biomolecules such as proteins, nucleic acid, and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of RA. Hence, understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for RA. As common second messengers of many stress factors, reactive oxygen species (ROS) may act as a regulator of cellular responses to extracellular environmental signaling. Furthermore, increasing evidence indicates that ROS may act as a mediator of lipid accumulation, which is associated with dramatic changes in the transcriptome, proteome, and metabolome. However, the specific mechanisms of ROS involvement in the cross talk between extracellular stress signaling and intracellular lipid synthesis require further investigation.


Reactive oxygen species Cellular signaling Stress response Lipid accumulation 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Physical Chemistry and Nanoscience, Department of Chemistry, Faculty of ScienceAl Baha UniversityBaljurashiSaudi Arabia

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