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Silicon Nanowires as Contact Between the Cell Membrane and CMOS Circuits

  • P. Piedimonte
  • D. A. M. Feyen
  • M. Mercola
  • E. Messina
  • M. Renzi
  • F. PalmaEmail author
Conference paper
  • 15 Downloads
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 627)

Abstract

We describe an innovative approach to sensing bioelectric signals at high space-time resolution with low invasiveness based on growing small Silicon Nano Wires (SiNW) at low-temperature (200 °C). The resulting SiNWs are compatible with ICs, allowing on-site amplification of bioelectric signals. We report our preliminary results showing biocompatibility and neutrality of SiNWs used as seeding substrate for cells in culture. With this technology, we aim to produce a compact device allowing on-site, synched and high signal/noise recordings of a large amounts of biological signals from networks of excitable cells (e.g. neurons) or distinct subdomains of the cell membrane, thus providing super-resolved descriptions of the propagation of electric waveforms within living cells and networks.

Notes

Acknowledgements

Authors wish to thank LFoundry for the information on the technology LF11iS-BSI.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • P. Piedimonte
    • 1
  • D. A. M. Feyen
    • 2
  • M. Mercola
    • 2
  • E. Messina
    • 3
  • M. Renzi
    • 4
  • F. Palma
    • 5
    Email author
  1. 1.Basic and Applied Sciences for Engineering DepartmentSapienza University of RomeRomeItaly
  2. 2.Medicine and Cardiovascular Institute DepartmentStanford University School of MedicinePalo AltoUSA
  3. 3.Policlinico Umberto I, SapienzaRomeItaly
  4. 4.Physiology and Pharmacology DepartmentSapienza University of RomeRomeItaly
  5. 5.Electronics and Telecommunications Engineering DepartmentSapienza University of RomeRomeItaly

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