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CCL22 Signaling in the Tumor Environment

  • Natascha Röhrle
  • Max M. L. Knott
  • David AnzEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1231)

Abstract

T cell-mediated elimination of malignant cells is one cornerstone of endogenous and therapeutically induced antitumor immunity. Tumors exploit numerous regulatory mechanisms to suppress T cell immunity. Regulatory T cells (T regs) play a crucial role in this process due to their ability to inhibit antitumoral immune responses and they are known to accumulate in various cancer entities. The chemokine CCL22, predominately produced by dendritic cells (DCs), regulates T reg migration via binding to its receptor CCR4. CCL22 controls T cell immunity, both by recruiting T regs to the tumor tissue and by promoting the formation of DC-T reg contacts in the lymph node. Here, we review the current knowledge on the role of CCL22 in cancer immunity. After revising the principal mechanisms of CCL22-induced immune suppression, we address the factors leading to CCL22 expression and ways of targeting this chemokine therapeutically. Therapeutic interventions to the CCL22-CCR4 axis may represent a promising strategy in cancer immunotherapy.

Keywords

CCL22 CCR4 Regulatory T cells Dendritic cells Chemokines T cell immunity Immune checkpoint Immunosuppression Tumor environment Lymph node Antitumor immunity Immune escape Immunotherapy IL-1 α Prostaglandin E2 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Natascha Röhrle
    • 1
  • Max M. L. Knott
    • 2
  • David Anz
    • 1
    • 3
    Email author
  1. 1.Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical PharmacologyKlinikum der Ludwig-Maximilians-Universität MünchenMunichGermany
  2. 2.Institute of Pathology of the Ludwig-Maximilians-Universität MünchenMunichGermany
  3. 3.Department of Internal Medicine II, Division of Gastroenterology and HepatologyKlinikum der Ludwig-Maximilians-Universität MünchenMunichGermany

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