CCL21 Programs Immune Activity in Tumor Microenvironment

  • Sherven SharmaEmail author
  • Pournima Kadam
  • Steven Dubinett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1231)


CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated immune activity in the TME. Immune escape mechanisms are upregulated in the TME that promote tumor immune evasion. CCL21 combined with inhibition of dominant pathways of immune evasion will aid in the development of effective immunotherapy for cancer.


CCL21 Tumor microenvironment T cells Dendritic cells Antigen-presenting cells Activated T cells Immune activity Programmed cell death protein 1 (PD-1) Immune checkpoint blockade Immune suppression Immunotherapy 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sherven Sharma
    • 1
    • 2
    • 3
    Email author
  • Pournima Kadam
    • 2
  • Steven Dubinett
    • 1
    • 2
    • 3
  1. 1.Department of Medicine, UCLA Lung Cancer Research ProgramDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare SystemLos AngelesUSA
  3. 3.Jonsson Comprehensive Cancer CenterDavid Geffen School of Medicine at UCLALos AngelesUSA

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