Therapeutic Hypothermia in Neurocritical Care

  • Vishank Arun ShahEmail author
  • Romergryko G. Geocadin
Part of the Current Clinical Neurology book series (CCNEU)


The neuroprotective benefits of therapeutic hypothermia (TH) have been known for several decades but have become conventional in clinical practice only over the last decade, after large randomized clinical trials (RCT) affirmed the benefits of TH in preventing neurologic injury, predominantly in cardiac arrest survivors. In neurocritical care, the applications of TH have been extended to several critical neurologic illnesses including refractory elevation in intracranial pressure (ICP), status epilepticus, ischemic stroke, and traumatic brain injury among others. The appropriate clinical use of TH requires understanding the postulated pathophysiologic mechanisms behind TH-induced neuroprotection, associated wanted and unwanted physiologic effects of TH, methods of inducing TH, and clinical care of patients during TH. All of these aspects will be addressed in this chapter.


Therapeutic hypothermia Cardiac arrest Brain injury Fever Shivering Rewarming 


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Authors and Affiliations

  1. 1.Department of Neurology and NeurosurgeryUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of Anesthesiology and Critical Care MedicineJohns Hopkins University School of MedicineBaltimoreUSA

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