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Cancer Stem Cell Niche and Immune-Active Tumor Microenvironment in Testicular Germ Cell Tumors

  • Katarina Kalavska
  • Lucia Kucerova
  • Silvia Schmidtova
  • Michal Chovanec
  • Michal Mego
Chapter
  • 91 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1226)

Abstract

Testicular germ cell tumors (TGCTs) represent the most common neoplasia among young men. Management of TGCTs is an excellent example of curative outcomes in clinical oncology. The unique sensitivity to cisplatin-based chemotherapy regimens has led to establishing TGCTs as a “model of cancer cure.” However, mechanisms and factors underlying pervasive growth of TGCTs are still poorly understood. It is suggested that unique cancer stem cell (CSC) niche exists in the testicular tumor microenvironment. CSC niche potentially contributes to the progression of germ cell tumors. Furthermore, rich infiltration of TGCTs with immune cells indicates involvement of immune system in biology of this cancer type. This review summarizes current knowledge regarding specific cancer microenvironment in TGCTs and discusses the role of cancer stem cells as well as immune mechanisms in these tumors.

Keywords

Testicular germ cell tumors Microenvironment Spermatogonial stem cell niche Pluripotency Cancer stem cells Germ cell neoplasia in situ Embryonal carcinoma Hypoxia Immunity Immune privilege Immune cell infiltration Cytokines Gene polymorphism WNT/βcatenin Immune-related biomarkers 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Katarina Kalavska
    • 1
    • 2
  • Lucia Kucerova
    • 2
  • Silvia Schmidtova
    • 2
  • Michal Chovanec
    • 3
  • Michal Mego
    • 1
    • 2
    • 3
  1. 1.Translational Research Unit, Faculty of MedicineComenius University and National Cancer InstituteBratislavaSlovakia
  2. 2.Department of Molecular OncologyCancer Research Institute, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of SciencesBratislavaSlovakia
  3. 3.Faculty of Medicine, 2nd Department of OncologyComenius University and National Cancer InstituteBratislavaSlovakia

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