Rheumatological Manifestations of HIV Infection

  • Kogielambal ChinniahEmail author


The protean manifestations of HIV infection derive from its complex dysregulation of the immune system. The spectrum of rheumatological disorders reported in children living with HIV infection include arthralgia, arthritis, myopathies, vasculopathies, systemic lupus erythematosus, diffuse infiltrative lymphocytosis syndrome, and complications of highly active antiretroviral therapy. The advent of highly active antiretroviral therapy has significantly improved the prognosis and changed the profile of rheumatologic disorders. This chapter reviews the pathogenesis, the clinical presentations and the treatment of the rheumatological disorders associated with HIV infection in children.


Arthralgia Arthritis HIV associated arthritis Reactive arthritis Spondyloarthropathy Polymyositis Myopathy Vasculitis Highly active antiretroviral therapy Systemic lupus erythematosus 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Paediatrics and Child HealthNelson R Mandela School of Medicine, UKZNDurbanSouth Africa

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