Non-invasive Central Neuromodulation with Transcranial Magnetic Stimulation

  • Jeanette Hui
  • Pantelis Lioumis
  • Daniel M. Blumberger
  • Zafiris J. DaskalakisEmail author


Transcranial magnetic stimulation (TMS) is a non-invasive method for neuromodulation which involves the application of brief magnetic pulses to the cortex to induce intracortical currents below the area of stimulation. The manipulation of stimulation parameters can alter the spatial and temporal patterns of cortical activation. Combining TMS with neurophysiological and neuroimaging modalities, such as electroencephalography (EEG) and stereotactic neuronavigation, respectively, can allow for a cause-and-effect approach to study cortical processes in vivo with very good spatial and excellent temporal precision. Investigation of cortical network properties may allow for the development of predictors and biomarkers of the pathophysiology of brain disorders, which can help bridge the gap between basic research and clinical applications. Already, therapeutic TMS paradigms are being used to treat medication-resistant depression and can potentially be used to ameliorate symptoms in other psychiatric or neurological disorders. Furthermore, navigated TMS procedures are increasingly being used for preoperative functional mapping of motor and language regions and can improve postoperative outcomes. Thus, TMS carries tremendous promise to assess brain properties in healthy and diseased states and can be used to optimize the efficacy of brain stimulation treatments in clinical populations.


Transcranial magnetic stimulation Non-invasive neuromodulation Electroencephalography Electromyography Neuronavigation Psychiatric disorders Neurological disorders Preoperative mapping 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Jeanette Hui
    • 1
    • 2
  • Pantelis Lioumis
    • 1
  • Daniel M. Blumberger
    • 1
    • 3
  • Zafiris J. Daskalakis
    • 1
    • 3
    Email author
  1. 1.Temerty Centre for Therapeutic Brain InterventionCentre for Addiction and Mental HealthTorontoCanada
  2. 2.Institute of Medical ScienceUniversity of TorontoTorontoCanada
  3. 3.Department of Psychiatry, Institute of Medical ScienceUniversity of TorontoTorontoCanada

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