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Breast Reconstruction Using Scaffold-Based Tissue Engineering

  • Jan Janzekovic
  • Michael Wagels
  • Dietmar W. HutmacherEmail author
Chapter
  • 64 Downloads

Abstract

Regenerative medicine and tissue engineering is becoming increasingly utilised across a broad range of medical specialties. By implanting a 3D printed, patient-specific scaffold, novel adipose tissue can be allowed to grow and fill the contour of the breast following mastectomy, partial mastectomy or even for revision augmentation procedures. The biomechanics, chemical properties and degradation characteristics of the scaffold material are crucial considerations in determining the success and safety of breast regeneration using tissue engineering. Large animal trials show promising results, with scaffolds made from medical grade polycaprolactone (mPCL) able to produce clinically significant amount of adipose tissue in a pig model. Further optimisation of scaffold architecture, potential for drug delivery and human trials are on the near horizon for this emerging option in breast reconstruction.

Keywords

Scaffolds Breast tissue engineering Regenerative medicine 3D printing Additive biomanufacturing 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Jan Janzekovic
    • 1
  • Michael Wagels
    • 2
  • Dietmar W. Hutmacher
    • 3
    Email author
  1. 1.Institute of Health and Biomedical Innovation, Queensland University of TechnologyBrisbaneAustralia
  2. 2.Institute of Health and Biomedical Innovation, Queensland University of Technology, Australian Centre for Complex Integrated Surgical Solutions, Department of Plastic and Reconstructive Surgery, Princess Alexandra HospitalBrisbaneAustralia
  3. 3.Institute of Health and Biomedical Innovation, Queensland University of Technology, ARC Centre in Additive BiomanufacturingBrisbaneAustralia

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