Advances in Polysaccharide-Based Antimicrobial Delivery Vehicles

  • Vaishali Pawar
  • M. C. Bavya
  • K. Vimal Rohan
  • Rohit SrivastavaEmail author


Antimicrobial resistance is one of the major causes for morbidity and mortality in sepsis patients. Trying to circumvent the challenge with newer antibiotics has led to the drug misuse and bacterial recalcitrance. Recently, polysaccharides have proffered inexplicable contributions in the field of antimicrobial drug delivery. Structural hierarchy and tunability in biochemical and mechanical properties make polysaccharides unique. Some of the polysaccharides in the naïve state itself pose antimicrobial properties in inhibiting bacterial colonization via blocking carbohydrate receptor associated with host–bacterial responses. While, rest of the saccharides upon modification delivers antibacterial drugs onto targeted sites with sustained or burst release depending upon the need. Ongoing research keeps pace in promoting polysaccharides for local as well as systemic therapy due to its attractive features, mainly biocompatibility, mechanical strength, stimuli responsiveness, protein affinity and reduced toxicity. This chapter presents the updates of prominent polysaccharides involved in the field of antimicrobial drug delivery.


Polysaccharide Antimicrobial Drug delivery Antibiotic resistance Biocompatibility Biomaterial 


  1. 1.
    Suryavanshi AV, Borse V, Pawar V, Sindhu KR, Srivastava R (2016) Material advancements in bone-soft tissue fixation devices. Sci Adv Today 2:25236Google Scholar
  2. 2.
    Liu Y, Zheng Z, Zara JN, Hsu C, Soofer DE, Lee KS et al (2012) The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel. Biomaterials 33:8745–8756. Scholar
  3. 3.
    Riool M, De Boer L, Jaspers V, Loos CMVD, Wamel WB, Wu G et al (2014) Staphylococcus epidermidis originating from titanium implants infects surrounding tissue and immune cells. Acta Biomater 10:5202–5212. Scholar
  4. 4.
    Lu H, Liu Y, Guo J, Wu H, Wang J, Wu G (2016) Biomaterials with antibacterial and osteoinductive properties to repair infected bone defects. Int J Mol Sci 17:334–352. Scholar
  5. 5.
    Borse V, Pawar V, Shetty G, Mullaji A, Srivastava R (2016) Nanobiotechnology perspectives on prevention and treatment of ortho-paedic implant associated infection. Curr Drug Deliv 13:175–185. Scholar
  6. 6.
    Biedenbach DJ, Moet GJ, Jones RN (2004) Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program (1997-2002). Diagn Microbiol Infect Dis 50:59–69. Scholar
  7. 7.
    Brusselaers N, Vogelaers D, Blot S (2011) The rising problem of antimicrobial resistance in the intensive care unit. Ann Intensive Care 1:47–54. Scholar
  8. 8.
    Campoccia D, Montanaro L, Arciola CR (2013) A review of the clinical implications of anti-infective biomaterials and infection-resistant surfaces. Biomaterials 34:8018–8029. Scholar
  9. 9.
    Mohammadi M, Mousavi Shaegh SA, Alibolandi M, Ebrahimzadeh MH, Tamayol A, Jaafari MR et al (2018) Micro and nanotechnologies for bone regeneration: recent advances and emerging designs. J Control Release 274:35–55. Scholar
  10. 10.
    Engelking L (2008) Polysaccharides and carbohydrate structure. In: Textbook of veterinary physiological chemistry, 3rd edn. Elsevier, Amsterdam, pp 270–279. Scholar
  11. 11.
    Liu Z, Jiao Y, Wang Y, Zhou C, Zhang Z (2008) Polysaccharides-based nanoparticles as drug delivery systems. Adv Drug Deliv Rev 60:1650–1662. Scholar
  12. 12.
    Bacic A, Fincher GB, Stone AB (2009) Chemistry, biochemistry, and biology of 1-3 Beta glucans and related polysaccharides, 1st edn. Elsevier, Amsterdam, pp 1–350. Scholar
  13. 13.
    Gupta BS, Edwards JV (2009) Textile materials and structures for wound care products. In: Rajendran S (ed) Advanced textiles for wound care. Woodhead Publishing Series in Textiles, Boca Raton, New York, London, pp 48–96. Scholar
  14. 14.
    Sebaaly C, Kassem S, Grishina E, Kanaan H, Sweidan A, Chmit MS et al (2014) Anticoagulant and antibacterial activities of polysaccharides of red algae Corallina collected from lebanese coast. J Appl Pharm Sci 4:30–37. Scholar
  15. 15.
    Thunyakipisal P, Saladyanant T, Hongprasong N, Pongsamart S, Apinhasmit W (2010) Antibacterial activity of polysaccharide gel extract from fruit rinds of durio zibethinus murr. against oral pathogenic bacteria. J Investig Clin Dent 89:74–75. Scholar
  16. 16.
    Zhang N, Wardwell PR, Bader RA (2013) Polysaccharide-based micelles for drug delivery. Pharmaceutics 5:329–352. Scholar
  17. 17.
    Zheng Y, Bai L, Zhou Y, Tong R, Zeng M, Li X et al (2019) Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances. Int J Biol Macromol 121:1240–1253. Scholar
  18. 18.
    Wasupalli GK, Verma D (2018) Polysaccharides as biomaterials. In: Thomas S, Balakrishnan P, Sreekala MS (eds) Fundamental biomaterials: polymers. Woodhead Publishing Series in Biomaterials, London, pp 37–70. Scholar
  19. 19.
    Liu L, Li M, Yu M, Shen M, Wang Q, Yu Y et al (2019) Natural polysaccharides exhibit anti-tumor activity by targeting gut microbiota. Int J Biol Macromol 121:743–751. Scholar
  20. 20.
    Liu J, Willför S, Xu C (2015) A review of bioactive plant polysaccharides: biological activities, functionalization, and biomedical applications. Bioact Carbohydr Diet Fibre 5:31–61. Scholar
  21. 21.
    Han G, Wang F, Chen Q, Liu F, Shao X, Ling P (2017) Recent advances in polysaccharides for osteoarthritis therapy. Eur J Med Chem 139:926–935. Scholar
  22. 22.
    Shi L (2016) Bioactivities, isolation and purification methods of polysaccharides from natural products: a review. Int J Biol Macromol 92:37–48. Scholar
  23. 23.
    Lin Z, Zhang H (2004) Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin 25:1387–1395PubMedGoogle Scholar
  24. 24.
    Zheng R, Jie S, Hanchuan D, Moucheng W (2005) Characterization and immunomodulating activities of polysaccharide from Lentinus edodes. Int Immunopharmacol 5:811–820. Scholar
  25. 25.
    García-González CA, Alnaief M, Smirnova I (2011) Polysaccharide-based aerogels—promising biodegradable carriers for drug delivery systems. Carbohydr Polym 86:1425–1438. Scholar
  26. 26.
    Malafaya PB, Silva GA, Reis RL (2007) Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev 59:207–233. Scholar
  27. 27.
    Pawar V, Srivastava R (2016) Layered assembly of chitosan nanoparticles and alginate gel for management of post-surgical pain and infection. In: 16th Int. Conf. Nanotechnol. - IEEE NANO 2016, pp 241–244. Scholar
  28. 28.
    Pawar V, Topkar H, Srivastava R (2018) Chitosan nanoparticles and povidone iodine containing alginate gel for prevention and treatment of orthopedic implant associated infections. Int J Biol Macromol 115:1131–1141. Scholar
  29. 29.
    Pawar V, Borse V, Thakkar R, Srivastava R (2018) Dual-purpose injectable doxorubicin conjugated alginate gel containing polycaprolactone microparticles for anti-cancer and anti-inflammatory therapy. Curr Drug Deliv 15:716–726. Scholar
  30. 30.
    Mehling T, Smirnova I, Guenther U, Neubert RHH (2009) Polysaccharide-based aerogels as drug carriers. J Non Cryst Solids 355:2472–2479. Scholar
  31. 31.
    Dang JM, Leong KW (2006) Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 58:487–499. Scholar
  32. 32.
    Gaber M, Mabrouk MT, Freag MS, Khiste SK, Fang JY, Elkhodairy KA et al (2018) Protein-polysaccharide nanohybrids: hybridization techniques and drug delivery applications. Eur J Pharm Biopharm 133:42–62. Scholar
  33. 33.
    Khemakhem I, Abdelhedi O, Trigui I, Ayadi MA, Bouaziz M (2018) Structural, antioxidant and antibacterial activities of polysaccharides extracted from olive leaves. Int J Biol Macromol 106:425–432. Scholar
  34. 34.
    Hirosawa S, Takahashi Y, Hashizume H, Miyake T, Akamatsu Y (2014) Synthesis and antibacterial activity of tripropeptin C derivatives modified at the carboxyl groups. J Antibiot (Tokyo) 67:265–268. Scholar
  35. 35.
    Ma YL, Zhu DY, Thakur K, Wang CH, Wang H, Ren YF et al (2018) Antioxidant and antibacterial evaluation of polysaccharides sequentially extracted from onion (Allium cepa L.). Int J Biol Macromol 111:92–101. Scholar
  36. 36.
    Agnihotri SA, Mallikarjuna NN, Aminabhavi TM (2004) Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release 100:5–28. Scholar
  37. 37.
    Ahmed S, Ikram S (2016) Chitosan based scaffolds and their applications in wound healing. Achiev Life Sci 10:27–37. Scholar
  38. 38.
    Niekraszewicz A (2005) Chitosan medical dressings. Fibres Text East Eur 13:16–18. Scholar
  39. 39.
    Harkins AL, Duri S, Kloth LC, Tran CD (2014) Chitosan-cellulose composite for wound dressing material. Part 2. Antimicrobial activity, blood absorption ability, and biocompatibility. J Biomed Mater Res Pt B Appl Biomater 102:1199–1206. Scholar
  40. 40.
    You J, Li W, Yu C, Zhao C, Jin L, Zhou Y et al (2013) Amphiphilically modified chitosan cationic nanoparticles for drug delivery. J Nanopart Res 15:1–10. Scholar
  41. 41.
    Pawar V, Dhanka M, Srivastava R (2018) Cefuroxime conjugated chitosan hydrogel for treatment of wound infections. Colloids Surf B Biointerfaces 173:776–787. Scholar
  42. 42.
    Qi L, Xu Z, Jiang X, Hu C, Zou X (2004) Preparation and antibacterial activity of chitosan nanoparticles. Carbohydr Res 339:2693–2700. Scholar
  43. 43.
    Ibrahim HM, El-Bisi MK, Taha GM, El-Alfy EA (2015) Chitosan nanoparticles loaded antibiotics as drug delivery biomaterial. J Appl Pharm Sci 5:85–90. Scholar
  44. 44.
    Madureira AR, Pereira A, Castro PM, Pintado M (2015) Production of antimicrobial chitosan nanoparticles against food pathogens. J Food Eng 167:210–216. Scholar
  45. 45.
    Elbi S, Biswas R, Baranwal G, Sathianarayanan S, Rajan VK, Jayakumar R et al (2017) Fucoidan coated ciprofloxacin loaded chitosan nanoparticles for the treatment of intracellular and biofilm infections of Salmonella. Colloids Surf B Biointerfaces 160:40–47. Scholar
  46. 46.
    Piras AM, Maisetta G, Sandreschi S, Gazzarri M, Bartoli C, Grassi L et al (2015) Chitosan nanoparticles loaded with the antimicrobial peptide temporin B exert a long-term antibacterial activity in vitro against clinical isolates of Staphylococcus epidermidis. Front Microbiol 6:1–10. Scholar
  47. 47.
    Pintado MM, Tavaria FK, Silva S, Costa EM, Veiga M (2018) Exploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms—from in vitro to ex vitro testing. Carbohydr Polym 201:340–346. Scholar
  48. 48.
    Wu T, Wu C, Fu S, Wang L, Yuan C, Chen S et al (2017) Integration of lysozyme into chitosan nanoparticles for improving antibacterial activity. Carbohydr Polym 155:192–200. Scholar
  49. 49.
    Jeon SJ, Oh M, Yeo WS, Galvão KN, Jeong KC (2014) Underlying mechanism of antimicrobial activity of chitosan microparticles and implications for the treatment of infectious diseases. PLoS One 9:e92723. Scholar
  50. 50.
    Ma Z, Kim D, Adesogan AT, Ko S, Galvao K, Jeong KC (2016) Chitosan microparticles exert broad-spectrum antimicrobial activity against antibiotic-resistant micro-organisms without increasing resistance. ACS Appl Mater Interfaces 8:10700–10709. Scholar
  51. 51.
    Jeon SJ, Ma Z, Kang M, Galvão KN, Jeong KC (2016) Application of chitosan microparticles for treatment of metritis and in vivo evaluation of broad spectrum antimicrobial activity in cow uteri. Biomaterials 110:71–80. Scholar
  52. 52.
    Shen J, Jin B, Qi YC, Jiang Q, Gao XF (2017) Carboxylated chitosan/silver-hydroxyapatite hybrid microspheres with improved antibacterial activity and cytocompatibility. Mater Sci Eng C 78:589–597. Scholar
  53. 53.
    Liu Z, Wang C, Liu Y, Peng D (2017) Cefepime loaded O-carboxymethyl chitosan microspheres with sustained bactericidal activity and enhanced biocompatibility. J Biomater Sci Polym Ed 28:79–92. Scholar
  54. 54.
    Mantripragada VP, Jayasuriya AC (2016) Effect of dual delivery of antibiotics (vancomycin and cefazolin) and BMP-7 from chitosan microparticles on Staphylococcus epidermidis and pre-osteoblasts in vitro. Mater Sci Eng C 67:409–417. Scholar
  55. 55.
    Saranya TS, Rajan VK, Biswas R, Jayakumar R, Sathianarayanan S (2018) Synthesis, characterisation and biomedical applications of curcumin conjugated chitosan microspheres. Int J Biol Macromol 110:227–233. Scholar
  56. 56.
    Thaya R, Vaseeharan B, Sivakamavalli J, Iswarya A, Govindarajan M, Alharbi NS et al (2018) Synthesis of chitosan-alginate microspheres with high antimicrobial and antibiofilm activity against multi-drug resistant microbial pathogens. Microb Pathog 114:17–24. Scholar
  57. 57.
    Abdelbary G (2011) Ocular ciprofloxacin hydrochloride mucoadhesive chitosan-coated liposomes. Pharm Dev Technol 16:44–56. Scholar
  58. 58.
    Norowski PA, Courtney HS, Babu J, Haggard WO, Bumgardner JD (2011) Chitosan coatings deliver antimicrobials from titanium implants: a preliminary study. Implant Dent 20:56–67. Scholar
  59. 59.
    Noel SP, Courtney H, Bumgardner JD, Haggard WO (2008) Chitosan films: a potential local drug delivery system for antibiotics. Clin Orthop Relat Res 466:1377–1382. Scholar
  60. 60.
    Smith JK, Bumgardner JD, Courtney HS, Smeltzer MS, Haggard O (2015) Antibiotic-loaded chitosan film for infection prevention: a preliminary in vitro characterization. J Biomed Mater Res Pt B Appl Biomater 94:203–211. Scholar
  61. 61.
    Oungbho K, Müller BW (1997) Chitosan sponges as sustained release drug carriers. Int J Pharm 156:229–237. Scholar
  62. 62.
    Chen Aimin DZ, Chunlin H, Juliang B, Tinyin Z (1999) Antibiotic loaded chitosan bar—an in vitro, in vivo study of a possible treatment for osteomyelitis. Clin Orthop Relat Res 366:239–247. PMID: 10627741CrossRefGoogle Scholar
  63. 63.
    Noel SP, Courtney HS, Bumgardner JD, Haggard WO (2010) Chitosan sponges to locally deliver amikacin and vancomycin: a pilot in vitro evaluation. Clin Orthop Relat Res:2074–2080.
  64. 64.
    Huang L, Dai T, Xuan Y, Tegos GP, Hamblin MR (2011) Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother 55:3432–3438. Scholar
  65. 65.
    Hao JY, Mi FL, Shyu SS, Wu YB, Schoung JY, Tsai YH et al (2002) Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery. J Biomed Mater Res 59:438–449. Scholar
  66. 66.
    Phaechamud T, Charoenteeraboon J (2008) Antibacterial activity and drug release of chitosan sponge containing doxycycline hyclate. AAPS PharmSciTech 9:829–835. Scholar
  67. 67.
    Pawar V, Bulbake U, Khan W, Srivastava R (2019) Chitosan sponges as a sustained release carrier system for theprophylaxis of orthopedic implant-associated infections. Int J Biol Macromol 134:100–112. Scholar
  68. 68.
    Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 62:83–99. Scholar
  69. 69.
    Harris M, Alexander C, Wells CM, Bumgardner JD, Carpenter DP, Jennings JA (2017) Chitosan for the delivery of antibiotics. In: Jessica Jennings JB (ed) Chitosan based biomater, 1st edn. Elsevier Publishing, Amsterdam, pp 147–173. Scholar
  70. 70.
    Meng G, He J, Wu Y, Wu F, Gu Z (2014) Antibiotic-loaded chitosan hydrogel with superior dual functions: antibacterial efficacy and osteoblastic cell responses. ACS Appl Mater Interfaces 6:10005–10013. Scholar
  71. 71.
    Chen CP, Hsieh CM, Tsai T, Yang JC, Chen CT (2015) Optimization and evaluation of a chitosan/hydroxypropyl methylcellulose hydrogel containing toluidine blue O for antimicrobial photodynamic inactivation. Int J Mol Sci 16:20859–20872. Scholar
  72. 72.
    Grumezescu AM, Andronescu E, Ficai A, Bleotu C, Mihaiescu DE, Chifiriuc MC (2012) Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells. Int J Pharm 436:771–777. Scholar
  73. 73.
    Skjk-Braek G, Grasdalen H, Larsen B (1986) Monomer sequence and acetylation pattern in some bacterial alginates. Carbohydr Res 154:239–250. Scholar
  74. 74.
    Sachan NK, Pushkar S, Jha A, Bhattcharya A (2009) Sodium alginate: the wonder polymer for controlled drug delivery. J Pharm Res 2:1191–1199Google Scholar
  75. 75.
    Dawn Hunt S (2016) Self-care and postoperative dressing management. Br J Nurs 25:1–6. Scholar
  76. 76.
    Cooper C (2013) Fundamentals of hand therapy: clinical reasoning and treatment guidelines for common diagnoses of the upper extremity. In: Cooper C (ed) Wound care, 2nd edn. Elsevier, Amsterdam, pp 206–218. Scholar
  77. 77.
    Leveriza-Oh M, Phillips TJ (2012) Dressings and postoperative care. In: Dockery GD, Crawford ME (eds) Lower extremtremity soft tissue cutaneous plastic surgery, 2nd edn. Elsevier, Amsterdam, pp 478–488. Scholar
  78. 78.
    Rinaudo M (2014) Biomaterials based on a natural polysaccharide: alginate. TIP 17:92–96. Scholar
  79. 79.
    Koehler J, Brandl FP, Goepferich AM (2018) Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. Eur Polym J 100:1–11. Scholar
  80. 80.
    Percival SL, McCarty SM (2014) Silver and alginates: role in wound healing and biofilm control. Adv Wound Care 4:407–414. Scholar
  81. 81.
    Simoes D, Miguel SP, Ribeiro MP, Coutinho P, Mendonça AG, Correia IJ (2018) Recent advances on antimicrobial wound dressing: a review. Eur J Pharm Biopharm 127:130–141. Scholar
  82. 82.
    Wiegand C, Heinze T, Hipler UC (2009) Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate. Wound Repair Regen 17:511–521. Scholar
  83. 83.
    Rafiq M, Hussain T, Abid S, Nazir A, Masood R (2018) Development of sodium alginate/PVA antibacterial nanofibers by the incorporation of essential oils. Mater Res Express 5:035007. Scholar
  84. 84.
    Varaprasad K, Raghavendra GM, Jayaramudu T, Seo J (2016) Nano zinc oxide-sodium alginate antibacterial cellulose fibres. Carbohydr Polym 135:349–355. Scholar
  85. 85.
    Paques JP, Van Der Linden E, Van Rijn CJM, Sagis LMC (2014) Preparation methods of alginate nanoparticles. Adv Colloid Interface Sci 209:163–171. Scholar
  86. 86.
    Li P, Dai YN, Zhang JP, Wang AQ, Wei Q (2008) Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine. Int J Biomed Sci 4:221–228. PMID: 23675094PubMedPubMedCentralGoogle Scholar
  87. 87.
    Trandafilović LV, Božanić DK, Dimitrijević-Branković S, Luyt AS, Djoković V (2012) Fabrication and antibacterial properties of ZnO-alginate nanocomposites. Carbohydr Polym 88:263–269. Scholar
  88. 88.
    Pandey S, Ramontja J (2016) Sodium alginate stabilized silver nanoparticles–silica nanohybrid and their antibacterial characteristics. Int J Biol Macromol 93:712–723. Scholar
  89. 89.
    Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A et al (2013) Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. J Invest Dermatol 133:1231–1239. Scholar
  90. 90.
    Liu J, Xiao J, Li F, Shi Y, Li D, Huang Q (2018) Chitosan-sodium alginate nanoparticle as a delivery system for ε-polylysine: preparation, characterization and antimicrobial activity. Food Control 91:302–310. Scholar
  91. 91.
    Costa JR, Silva NC, Sarmento B, Pintado M (2015) Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin. Eur J Clin Microbiol Infect Dis 34:1255–1262. Scholar
  92. 92.
    Ozseker EE, Akkaya A (2016) Development of a new antibacterial biomaterial by tetracycline immobilization on calcium-alginate beads. Carbohydr Polym 151:441–451. Scholar
  93. 93.
    Guler S, Ozseker EE, Akkaya A (2016) Developing an antibacterial biomaterial. Eur Polym J 84:326–337. Scholar
  94. 94.
    Hebeish A, Ramadan M, Montaser A, Krupa I, Farag A (2015) Molecular characteristics and antibacterial activity of alginate beads coated chitosan polyacrylonitrile copolymer loaded silver nanocomposite. J Sci Res Rep 5:479–488. Scholar
  95. 95.
    George M, Abraham TE (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan—a review. J Control Release 114:1–14. Scholar
  96. 96.
    Nam SY, Nho YC, Hong SH, Chae GT, Jang HS, Suh TS et al (2004) Evaluations of poly(vinyl alcohol)/alginate hydrogels cross-linked by γ-ray irradiation technique. Macromol Res 12:219–224. Scholar
  97. 97.
    George L, Bavya MC, Rohan KV, Srivastava R (2017) A therapeutic polyelectrolyte–vitamin C nanoparticulate system in polyvinyl alcohol–alginate hydrogel: an approach to treat skin and soft tissue infections caused by Staphylococcus aureus. Colloids Surf B Biointerfaces 160:315–324. Scholar
  98. 98.
    Kesavan K, Nath G, Pandit JK (2010) Sodium alginate based mucoadhesive system for gatifloxacin and its in vitro antibacterial activity. Sci Pharm 78:941–957. Scholar
  99. 99.
    Sharma S, Sanpui P, Chattopadhyay A, Ghosh SS (2012) Fabrication of antibacterial silver nanoparticle—sodium alginate-chitosan composite films. RSC Adv 2:5837–5843. Scholar
  100. 100.
    Whistler RL, BeMiller JN (2012) Industrial gums: polysaccharides and their derivatives, 3rd edn. Wiley Academic Press, San Diego, New York, Boston, pp 234–251. Scholar
  101. 101.
    Roy S, Rhim JW (2019) Carrageenan-based antimicrobial bionanocomposite films incorporated with ZnO nanoparticles stabilized by melanin. Food Hydrocoll 90:500–507. Scholar
  102. 102.
    Shojaee-Aliabadi S, Hosseini H, Mohammadifar MA, Mohammadi A, Ghasemlou M, Hosseini SM et al (2014) Characterization of κ-carrageenan films incorporated plant essential oils with improved antimicrobial activity. Carbohydr Polym 101:582–591. Scholar
  103. 103.
    Briones AV, Sato T, Bigol UG (2014) Antibacterial activity of polyethylenimine/carrageenan multilayer against pathogenic bacteria. Adv Chem Eng Sci 4:233–241. Scholar
  104. 104.
    El-Fawal G (2014) Preparation, characterization and antibacterial activity of biodegradable films prepared from carrageenan. J Food Sci Technol 51:2234–2239. Scholar
  105. 105.
    Cevher E, Mülazimoglu L, Gürcan D, Alper M, Araman A, Özsoy Y (2006) The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres their evaluation in an animal osteomyelitis model. J Bone Joint Surg Br 88:270–275. Scholar
  106. 106.
    Dacarro G, Curtosi S, Milanese C, D’Agostino A, Bertoglio F, Taglietti A et al (2017) Silver nanoparticles synthesized and coated with pectin: an ideal compromise for anti-bacterial and anti-biofilm action combined with wound-healing properties. J Colloid Interface Sci 498:271–281. Scholar
  107. 107.
    Martínez YN, Cavello I, Hours R, Cavalitto S, Castro GR (2013) Immobilized keratinase and enrofloxacin loaded on pectin PVA cryogel patches for antimicrobial treatment. Bioresour Technol 145:280–284. Scholar
  108. 108.
    Bayón B, Bucalá V, Castro GR (2016) Development of antimicrobial hybrid mesoporous silver phosphate-pectin microspheres for control release of levofloxacin. Micropor Mesopor Mater 226:71–78. Scholar
  109. 109.
    da Silva EP, Sitta DA, Fragal VH, Cellet TP, Mauricio MR, Garcia FP et al (2014) Covalent TiO2/pectin microspheres with Fe3O4 nanoparticles for magnetic field-modulated drug delivery. Int J Biol Macromol 67:43–52. Scholar
  110. 110.
    Nešić A, Onjia A, Davidović S, Dimitrijević S, Errico ME, Santagata G et al (2017) Design of pectin-sodium alginate based films for potential healthcare application: study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity. Carbohydr Polym 157:981–990. Scholar
  111. 111.
    Polifka JE, Habermann J (2014) Anticoagulants, thrombocyte aggregation inhibitors, fibrinolytics and volume replacement agents. In: Schaefer RKMC, Peters P (eds) Drugs during pregnancy and lactation: treatment options and risk assessment, 3rd edn. Elsevier, Amsterdam, pp 225–249. Scholar
  112. 112.
    Sagitha P, Reshmi CR, Sundaran SP, Binoy A, Mishra N, Sujith A (2019) In-vitro evaluation on drug release kinetics and antibacterial activity of dextran modified polyurethane fibrous membrane. Int J Biol Macromol 126:717–730. Scholar
  113. 113.
    Yang G, Lin Q, Wang C, Li J, Wang J, Zhou J et al (2012) Synthesis and characterization of dextran-capped silver nanoparticles with enhanced antibacterial activity. J Nanosci Nanotechnol 12:3766–3774. Scholar
  114. 114.
    Hoque J, Haldar J (2017) Direct synthesis of dextran-based antibacterial hydrogels for extended release of biocides and eradication of topical biofilms. ACS Appl Mater Interfaces 9:15975–15985. Scholar
  115. 115.
    De Cicco F, Reverchon E, Adami R, Auriemma G, Russo P, Calabrese EC et al (2014) In situ forming antibacterial dextran blend hydrogel for wound dressing: SAA technology vs. spray drying. Carbohydr Polym 101:1216–1224. Scholar
  116. 116.
    Ritz U, Kögler P, Höfer I, Frank P, Klees S, Gebhard S et al (2016) Photocrosslinkable polysaccharide hydrogel composites based on dextran or pullulan-amylose blends with cytokines for a human co-culture model of human osteoblasts and endothelial cells. J Mater Chem B 4:6552–6564. Scholar
  117. 117.
    Liao N, Unnithan AR, Joshi MK, Tiwari AP, Hong ST, Park CH et al (2015) Electrospun bioactive poly (e{open}-caprolactone)-cellulose acetate-dextran antibacterial composite mats for wound dressing applications. Colloids Surfaces A Physicochem Eng Asp 469:194–201. Scholar
  118. 118.
    Tiyaboonchai W, Rodleang I, Ounaroon A (2015) Mucoadhesive polyethylenimine-dextran sulfate nanoparticles containing Punica granatum peel extract as a novel sustained-release antimicrobial. Pharm Dev Technol 20:426–432. Scholar
  119. 119.
    Bankura KP, Maity D, Mollick MR, Mondal D, Bhowmick B, Bain MK et al (2012) Synthesis, characterization and antimicrobial activity of dextran stabilized silver nanoparticles in aqueous medium. Carbohydr Polym 1110:156–161. Scholar
  120. 120.
    Unnithan AR, Barakat NM, Tirupathi Pichiah PB, Gnanasekaran G, Nirmala R, Cha YS et al (2012) Wound-dressing materials with antibacterial activity from electrospun polyurethane-dextran nanofiber mats containing ciprofloxacin HCl. Carbohydr Polym 90:1786–1793. Scholar
  121. 121.
    Cano AI, Cháfer M, Chiralt A, González-Martínez C (2015) Physical and microstructural properties of biodegradable films based on pea starch and PVA. J Food Eng 167:59–64. Scholar
  122. 122.
    Kaith BS, Sharma R, Kalia S (2015) Guar gum based biodegradable, antibacterial and electrically conductive hydrogels. Int J Biol Macromol 75:266–275. Scholar
  123. 123.
    Sharma R, Kaith BS, Kalia S, Pathania D, Kumar A, Sharma N et al (2015) Biodegradable and conducting hydrogels based on Guar gum polysaccharide for antibacterial and dye removal applications. J Environ Manage 162:37–45. Scholar
  124. 124.
    Auddy RG, Abdullah MF, Das S, Roy P, Datta S, Mukherjee A (2013) New guar biopolymer silver nanocomposites for wound healing applications. Biomed Res Int 2013:912458. Scholar
  125. 125.
    Necas J, Bartosikova L, Brauner P, Kolar J (2008) Hyaluronic acid (hyaluronan): a review. Vet Med (Praha) 53:397–411. Scholar
  126. 126.
    Lequeux I, Ducasse E, Jouenne T, Thebault P (2014) Addition of antimicrobial properties to hyaluronic acid by grafting of antimicrobial peptide. Eur Polym J 51:182–190. Scholar
  127. 127.
    Saranraj P, Naidu MA (2013) Hyaluronic acid production and its applications—a review. Int J Pharm Biol Arch 4:853–859. ISSN 0976-3333Google Scholar
  128. 128.
    Suzuki K, Anada T, Miyazaki T, Miyatake N, Honda Y, Kishimoto KN et al (2014) Effect of addition of hyaluronic acids on the osteoconductivity and biodegradability of synthetic octacalcium phosphate. Acta Biomater 10:531–543. Scholar
  129. 129.
    Rodan GA, Martin TJ (1981) Role of osteoblasts in hormonal control of bone resorption—a hypothesis. Calcif Tissue Int 33:349–351. Scholar
  130. 130.
    Pérez-Álvarez L, Ruiz-Rubio L, Azua I, Benito V, Bilbao A, Vilas-Vilela JL (2019) Development of multiactive antibacterial multilayers of hyaluronic acid and chitosan onto poly(ethylene terephthalate). Eur Polym J 112:31–37. Scholar
  131. 131.
    Ardizzoni A, Neglia RG, Baschieri MC, Cermelli C, Caratozzolo M, Righi E et al (2011) Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens. J Mater Sci Mater Med 22:2329–2338. Scholar
  132. 132.
    Gaetano G, Giuseppe P, Salvatore PF, Susanna M, Sara S, Luca RC (2018) Hyaluronic-based antibacterial hydrogel coating for implantable biomaterials in orthopedics and trauma: from basic research to clinical applications. In: Haider AH (ed) Hydrogels, 1st edn. IntechOpen, London, pp 179–200. Scholar
  133. 133.
    Petrauskaite O, Gomes PS, Fernandes MH, Juodzbalys G, Stumbras A, Maminskas J et al (2013) Biomimetic mineralization on a macroporous cellulose-based matrix for bone regeneration. Biomed Res Int 2013:1–9. Scholar
  134. 134.
    Cheng H, Yang X, Che X, Yang M, Zhai G (2018) Biomedical application and controlled drug release of electrospun fibrous materials. Mater Sci Eng C 90:750–763. Scholar
  135. 135.
    Khattak S, Wahid F, Liu LP, Jia SR, Chu LQ, Xie YY et al (2019) Applications of cellulose and chitin/chitosan derivatives and composites as antibacterial materials: current state and perspectives. Appl Microbiol Biotechnol 103:1989–2006. Scholar
  136. 136.
    Konwarh R, Karak N, Misra M (2013) Electrospun cellulose acetate nanofibers: the present status and gamut of biotechnological applications. Biotechnol Adv 31:421–437. Scholar
  137. 137.
    Jia B, Mei Y, Cheng L, Zhou J, Zhang L (2012) Preparation of copper nanoparticles coated cellulose films with antibacterial properties through one-step reduction. ACS Appl Mater Interfaces 4:2897–2902. Scholar
  138. 138.
    Foresti ML, Vázquez A, Boury B (2017) Applications of bacterial cellulose as precursor of carbon and composites with metal oxide, metal sulfide and metal nanoparticles: a review of recent advances. Carbohydr Polym 157:447–467. Scholar
  139. 139.
    Khoshnevisan K, Maleki H, Samadian H, Shahsavari S, Sarrafzadeh MH, Larijani B et al (2018) Cellulose acetate electrospun nanofibers for drug delivery systems: applications and recent advances. Carbohydr Polym 198:131–141. Scholar
  140. 140.
    Unnithan AR, Gnanasekaran G, Sathishkumar Y, Lee YS, Kim CS (2014) Electrospun antibacterial polyurethane-cellulose acetate-zein composite mats for wound dressing. Carbohydr Polym 102:884–892. Scholar
  141. 141.
    Liu S, Chu M, Zhu Y, Li L, Wang L, Gao H et al (2017) A novel antibacterial cellulose based biomaterial for hernia mesh applications. RSC Adv 7:11601–11607. Scholar
  142. 142.
    Azizi S, Ahmad MB, Hussein MZ, Ibrahim NA (2013) Synthesis, antibacterial and thermal studies of cellulose nanocrystal stabilized ZnO-Ag heterostructure nanoparticles. Molecules 18:6269–6280. Scholar
  143. 143.
    Baker S, Volova T, Prudnikova SV, Shumilova AA, Perianova OV, Zharkov SM et al (2018) Bio-hybridization of nanobactericides with cellulose films for effective treatment against members of ESKAPE multi-drug-resistant pathogens. Appl Nanosci 8:1101–1110. Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Vaishali Pawar
    • 1
  • M. C. Bavya
    • 1
  • K. Vimal Rohan
    • 2
  • Rohit Srivastava
    • 1
    Email author
  1. 1.Indian Institute of TechnologyMumbaiIndia
  2. 2.Pariyaram Medical CollegePariyaramIndia

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