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Advances in Polysaccharide-Based Antimicrobial Delivery Vehicles

  • Vaishali Pawar
  • M. C. Bavya
  • K. Vimal Rohan
  • Rohit SrivastavaEmail author
Chapter
  • 94 Downloads

Abstract

Antimicrobial resistance is one of the major causes for morbidity and mortality in sepsis patients. Trying to circumvent the challenge with newer antibiotics has led to the drug misuse and bacterial recalcitrance. Recently, polysaccharides have proffered inexplicable contributions in the field of antimicrobial drug delivery. Structural hierarchy and tunability in biochemical and mechanical properties make polysaccharides unique. Some of the polysaccharides in the naïve state itself pose antimicrobial properties in inhibiting bacterial colonization via blocking carbohydrate receptor associated with host–bacterial responses. While, rest of the saccharides upon modification delivers antibacterial drugs onto targeted sites with sustained or burst release depending upon the need. Ongoing research keeps pace in promoting polysaccharides for local as well as systemic therapy due to its attractive features, mainly biocompatibility, mechanical strength, stimuli responsiveness, protein affinity and reduced toxicity. This chapter presents the updates of prominent polysaccharides involved in the field of antimicrobial drug delivery.

Keywords

Polysaccharide Antimicrobial Drug delivery Antibiotic resistance Biocompatibility Biomaterial 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Vaishali Pawar
    • 1
  • M. C. Bavya
    • 1
  • K. Vimal Rohan
    • 2
  • Rohit Srivastava
    • 1
    Email author
  1. 1.Indian Institute of TechnologyMumbaiIndia
  2. 2.Pariyaram Medical CollegePariyaramIndia

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