Construction of Bio-functionalized ZnO Coatings on Titanium Implants with Both Self-Antibacterial and Osteoinductive Properties

  • Lei Tan
  • Xiangmei Liu
  • Shuilin WuEmail author


Bacterial infection and lack of osteoinductive ability are the major concerns of titanium-based bone implants. This chapter describes the construction of bio-functionalized ZnO coatings with both self-antibacterial and osteoinductive properties on titanium implants. To obtain ZnO-modified coatings with strong binding forces with substrates, two preparation methods are presented including atomic layer deposition and laser cladding techniques. Next, the antibacterial and osteoinductive properties of ZnO-based coatings are described including Ag/ZnO/hydroxyapatite-Ti, Ti-ZnO/polydopamine/arginine-glycine-aspartic acid-cysteine and poly(lactic-co-glycolic acid)/Ag/ZnO-Ti. We summarize the balancing strategies of reducing cytotoxicity of ZnO to bone cells and enhancing its toxicity towards bacteria.


Titanium implant ZnO Self-antibacterial Osteoinductive Atomic layer deposition Laser cladding Controlled release Balancing 



This work was partially supported by the National Natural Science Foundation of China, Nos. 51801056, 51671081, 51871162, and 51422102, and the National Key Research and Development Program of China No. 2016YFC1100600 (subproject 2016YFC1100604), and the Natural Science Fund of Hubei Province, 2018CFA064. The authors also gratefully acknowledge the helpful comments and suggestions of the reviewers, which have improved the presentation.


  1. 1.
    Li J, Tan L, Liu X et al (2017) Balancing bacteria–osteoblast competition through selective physical puncture and biofunctionalization of ZnO/polydopamine/arginine-glycine-aspartic acid-cysteine nanorods. ACS Nano 11:11250–11263CrossRefGoogle Scholar
  2. 2.
    Jung Kyu P, Yong-Jin K, Junseok Y et al (2010) The topographic effect of zinc oxide nanoflowers on osteoblast growth and osseointegration. Adv Mater 22:4857–4861CrossRefGoogle Scholar
  3. 3.
    Zhu Y, Liu X, Yeung KWK, Chu PK, Wu S (2016) Biofunctionalization of carbon nanotubes/chitosan hybrids on Ti implants by atom layer deposited ZnO nanostructures. Appl Surf Sci 400:14–23CrossRefGoogle Scholar
  4. 4.
    Zhang Y, Liu X, Li Z et al (2017) Nano Ag/ZnO incorporated hydroxyapatite composite coatings: highly effective infection prevention and excellent osteointegration. ACS Appl Mater Interfaces 10:1266–1277CrossRefGoogle Scholar
  5. 5.
    Suntola T, Antson J (1977) Method for producing compound thin films: U.S. Patent 4,058,430 [P]. 11–15Google Scholar
  6. 6.
    George SM (2010) Atomic layer deposition: an overview. Chem Rev 110:111–131CrossRefGoogle Scholar
  7. 7.
    Park JW, Kim Y, Park C et al (2009) Enhanced osteoblast response to an equal channel angular pressing-processed pure titanium substrate with microrough surface topography. Acta Biomater 5:3272–3280CrossRefGoogle Scholar
  8. 8.
    Comesaña R, Quintero F, Lusquiños F et al (2010) Laser cladding of bioactive glass coatings. Acta Biomater 6:953–961CrossRefGoogle Scholar
  9. 9.
    Xiang Y, Li J, Liu X et al (2017) Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility. Mater Sci Eng C 79:629–637CrossRefGoogle Scholar
  10. 10.
    Wang T, Liu X, Zhu Y et al (2017) Metal ion coordination polymer-capped pH-triggered drug release system on titania nanotubes for enhancing self-antibacterial capability of Ti implants. ACS Biomater Sci Eng 3:816–825CrossRefGoogle Scholar
  11. 11.
    Li Y, Liu X, Tan L et al (2017) Construction of N-halamine labeled silica/zinc oxide hybrid nanoparticles for enhancing antibacterial ability of Ti implants. Mater Sci Eng C 76:50–58CrossRefGoogle Scholar
  12. 12.
    Zhang K, Zhu Y, Liu X et al (2017) Sr/ZnO doped titania nanotube array: an effective surface system with excellent osteoinductivity and self-antibacterial activity. Mater Des 130:403–412CrossRefGoogle Scholar
  13. 13.
    Tan L, Li J, Liu X et al (2018) Rapid biofilm eradication on bone implants using red phosphorus and near-infrared light. Adv Mater 30:1801808CrossRefGoogle Scholar
  14. 14.
    Li J, Liu X, Tan L et al (2019) Light-activated rapid disinfection by accelerated charge transfer in red phosphorus/ZnO heterointerface. Small Methods 3:1900048CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and EngineeringHubei UniversityWuhanChina
  2. 2.School of Materials Science and EngineeringTianjin UniversityTianjinChina

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