Construction of Bio-functionalized ZnO Coatings on Titanium Implants with Both Self-Antibacterial and Osteoinductive Properties
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Bacterial infection and lack of osteoinductive ability are the major concerns of titanium-based bone implants. This chapter describes the construction of bio-functionalized ZnO coatings with both self-antibacterial and osteoinductive properties on titanium implants. To obtain ZnO-modified coatings with strong binding forces with substrates, two preparation methods are presented including atomic layer deposition and laser cladding techniques. Next, the antibacterial and osteoinductive properties of ZnO-based coatings are described including Ag/ZnO/hydroxyapatite-Ti, Ti-ZnO/polydopamine/arginine-glycine-aspartic acid-cysteine and poly(lactic-co-glycolic acid)/Ag/ZnO-Ti. We summarize the balancing strategies of reducing cytotoxicity of ZnO to bone cells and enhancing its toxicity towards bacteria.
KeywordsTitanium implant ZnO Self-antibacterial Osteoinductive Atomic layer deposition Laser cladding Controlled release Balancing
This work was partially supported by the National Natural Science Foundation of China, Nos. 51801056, 51671081, 51871162, and 51422102, and the National Key Research and Development Program of China No. 2016YFC1100600 (subproject 2016YFC1100604), and the Natural Science Fund of Hubei Province, 2018CFA064. The authors also gratefully acknowledge the helpful comments and suggestions of the reviewers, which have improved the presentation.
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