Cationic Antimicrobial Coatings with Osteoinductive Properties

  • Qing Song
  • Yangyang Pei
  • Xiaoting Ye
  • Peng LiEmail author
  • Wei Huang


Orthopedic implant-associated infections caused by pathogenic bacteria, especially the Staphylococcus genus, have been a medical and surgical challenge. The infections not only delay the healing process, and have patients suffer from severe pain and even be subjected to re-implantation, but also cause enormous economic losses. It is clear that both a reduction of bacterial infections and acceleration of bone healing are critical to improving the osseointegration of orthopedic implants. Recently, various antibacterial coatings have been employed for the surface modification of orthopedic implants to reduce the bacterial infections. Interestingly, it has been found that some antibacterial coatings, including polycations and metal cations, also possess osteoinductive properties, and thus effectively speed up the healing process. In this chapter, we will shed light on the antibacterial and osteogenic mechanisms of positively charged biomaterials and present some typical cationic antimicrobial coatings with osteoinductive properties in detail.


Polycations Copper Antibacterial Osteoinductive Angiogenesis 



This work was financially supported by the National Key R&D Program of China (2018YFC1105402 and 2017YFA0207202), the National Natural Science Foundation of China (21706222 and 21875189), Key R&D Program of Jiangsu Province (BE2017740), the open research fund of Key Laboratory for Organic Electronics and Information Displays, and the Fundamental Research Funds for the Central Universities.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Qing Song
    • 1
    • 2
  • Yangyang Pei
    • 1
  • Xiaoting Ye
    • 1
  • Peng Li
    • 1
    • 3
    Email author
  • Wei Huang
    • 1
    • 2
    • 3
  1. 1.MIIT Key Laboratory of Flexible Electronics & Shaanxi Key Laboratory of Flexible Electronics, Xi’an Key Laboratory of Flexible Electronics & Xi’an Key Laboratory of Biomedical Materials and Engineering, Xi’an Institute of Flexible Electronics (IFE) & Xi’an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU)Xi’anChina
  2. 2.Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM)Nanjing University of Posts & TelecommunicationsNanjingChina
  3. 3.Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)Nanjing Tech UniversityNanjingChina

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