Cationic Antimicrobial Coatings with Osteoinductive Properties
- 132 Downloads
Orthopedic implant-associated infections caused by pathogenic bacteria, especially the Staphylococcus genus, have been a medical and surgical challenge. The infections not only delay the healing process, and have patients suffer from severe pain and even be subjected to re-implantation, but also cause enormous economic losses. It is clear that both a reduction of bacterial infections and acceleration of bone healing are critical to improving the osseointegration of orthopedic implants. Recently, various antibacterial coatings have been employed for the surface modification of orthopedic implants to reduce the bacterial infections. Interestingly, it has been found that some antibacterial coatings, including polycations and metal cations, also possess osteoinductive properties, and thus effectively speed up the healing process. In this chapter, we will shed light on the antibacterial and osteogenic mechanisms of positively charged biomaterials and present some typical cationic antimicrobial coatings with osteoinductive properties in detail.
KeywordsPolycations Copper Antibacterial Osteoinductive Angiogenesis
This work was financially supported by the National Key R&D Program of China (2018YFC1105402 and 2017YFA0207202), the National Natural Science Foundation of China (21706222 and 21875189), Key R&D Program of Jiangsu Province (BE2017740), the open research fund of Key Laboratory for Organic Electronics and Information Displays, and the Fundamental Research Funds for the Central Universities.
- 6.Croes M, Bakhshandeh S, van Hengel IAJ, Lietaert K, van Kessel KPM, Pouran B, van der Wal BCH, Vogely HC, Van Hecke W, Fluit AC, Boel CHE, Alblas J, Zadpoor AA, Weinans H, Amin Yavari S (2018) Antibacterial and immunogenic behavior of silver coatings on additively manufactured porous titanium. Acta Biomater 81:315–327CrossRefGoogle Scholar
- 24.Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N (2008) Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system. J Bone Miner Res 23(5):633–643CrossRefGoogle Scholar