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The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development

  • Shahrzad BahrampourEmail author
  • Stefan ThorEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1218)

Abstract

During central nervous system (CNS) development, a complex series of events play out, starting with the establishment of neural progenitor cells, followed by their asymmetric division and formation of lineages and the differentiation of neurons and glia. Studies in the Drosophila melanogaster embryonic CNS have revealed that the Notch signal transduction pathway plays at least five different and distinct roles during these events. Herein, we review these many faces of Notch signalling and discuss the mechanisms that ensure context-dependent and compartment-dependent signalling. We conclude by discussing some outstanding issues regarding Notch signalling in this system, which likely have bearing on Notch signalling in many species.

Keywords

CNS development Notch signalling 

Notes

Author Contributions

SB and ST generated the figures and wrote the manuscript.

Competing Interests

No competing interests declared.

Funding

Funding was provided by the Swedish Research Council (2018-00694) to SB and by support from the University of Queensland to ST.

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Authors and Affiliations

  1. 1.The Hospital for Sick Children, Peter Gilgan Center for Research and LearningTorontoCanada
  2. 2.Karolinska Institutet, Department of Cell and Molecular Biology (CMB)StockholmSweden
  3. 3.School of Biomedical Sciences, University of QueenslandSt LuciaAustralia

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