Wnt Signaling: Paths for Cancer Progression

  • Filipa Carreira-Barbosa
  • Sofia C. Nunes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1219)


The Wnt signaling pathways are well known for having several pivotal roles during embryonic development. However, the same developmental signaling pathways also present key roles in cancer initiation and progression. In this chapter, several issues regarding the roles of both canonical and non-canonical Wnt signaling pathways in cancer will be explored, mainly concerning their role in the maintenance of cancer stemness, in the metabolism reprograming of cancer cells and in the modulation of the tumor microenvironment. The role of Wnt signaling cascades in the response of cancer cells to anti-cancer treatments will be also discussed, as well as its potential therapeutic targeting during cancer treatment. Collectively, increasing evidence has been supporting pivotal roles of Wnt signaling in several features of cancer biology, however; a lot is still to be elucidated.


Cancer Metabolism reprogramming Resistance Stemness Tumor microenvironment Wnt 



The authors acknowledge iNOVA4Health – UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Filipa Carreira-Barbosa
    • 1
  • Sofia C. Nunes
    • 2
    • 3
  1. 1.Faculdade de Ciências da Universidade de Lisboa (FCUL-UL)LisbonPortugal
  2. 2.CEDOC, Chronic Diseases Research Centre, NOVA Medical School | Faculdade de Ciências MédicasUniversidade NOVA de LisboaLisbonPortugal
  3. 3.Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG)LisbonPortugal

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