Weighted Least Squares for Adjusting Efficacy Data with Inconsistent Spread (78 Patients)

  • Ton J. Cleophas
  • Aeilko H. Zwinderman


Linear regression assumes that the spread of the outcome-values is homoscedastic: it is the same for each predictor value. This assumption is, however, not warranted in many real life situations. This chapter is to assess the advantages of weighted least squares (WLS) instead of ordinary least squares (OLS) linear regression analysis.

Supplementary material

333106_2_En_25_MOESM1_ESM.sav (4 kb)
weightedleastsquares (SAV 4 kb)

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ton J. Cleophas
    • 1
  • Aeilko H. Zwinderman
    • 2
  1. 1.Department Medicine Albert Schweitzer HospitalDordrechtThe Netherlands
  2. 2.Academic Medical CenterDepartment Biostatistics and EpidemiologyAmsterdamThe Netherlands

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