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Contact dermatitis is one of the most common clinical pictures observed in daily dermatological practice, with a prevalence in general population ranging from 1.7% to 6.3% in the short term and from 6.2% to 10.6% for long-term disorders. Among its various clinical features, irritant contact dermatitis is the one most commonly observed, especially in the occupational context. As regards the type of contact, a harmful chemical agent can reach the skin through two different routes, either exogenous or endogenous. The first one may be “direct” (the substance comes in direct contact with the skin) or “airborne” (the substance present in the environment comes in contact with the skin through the air). Endogenous contact occurs in already sensitized subjects with substances that can also be administered systematically. The diagnosis of contact dermatitis is based on medical history, clinical finding, and allergological tests.