Advertisement

Drug-Induced Liver Injury with Autoimmune Features

  • Paul A. SchmeltzerEmail author
Chapter
  • 18 Downloads

Abstract

Idiosyncratic drug-induced liver injury (DILI) can present with autoimmune features, including positive autoantibodies, hypergammaglobulinemia, and lymphoplasmocytic inflammation on liver biopsy. Differentiating between DILI and idiopathic autoimmune hepatitis (iAIH) can be challenging in part because it is often difficult to establish DILI causality. Drug discontinuation is the main treatment of DILI with autoimmune features, though immunosuppression is indicated in certain circumstances, such as DILI with immunoallergic features. This chapter will address how to differentiate between DILI and iAIH and discuss some of the drugs that are most commonly associated with an autoimmune phenotype.

Keywords

Hepatotoxicity Triggered Supplement Autoantibodies Smooth muscle antibody 

References

  1. 1.
    Boberg KM, Aadland E, Jahnsen J, et al. Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population. Scand J Gastroenterol. 1998;33:99–103.CrossRefGoogle Scholar
  2. 2.
    Bjornsson. Review article: drug-induced liver injury in clinical practice. Aliment Pharmacol Ther. 2010;32:3–13.CrossRefGoogle Scholar
  3. 3.
    Reuben A, Koch DG, Lee WM. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52:2065–76.CrossRefGoogle Scholar
  4. 4.
    Weiler-Normann C, Schramm C. Drug induced liver injury and its relationship to autoimmune hepatitis. J Hepatol. 2011;55:747–9.CrossRefGoogle Scholar
  5. 5.
    deLemos AS, Foureau DM, Jacobs C, et al. Drug-induced liver injury with autoimmune features. Semin Liver Dis. 2014;34:194–204.CrossRefGoogle Scholar
  6. 6.
    Robin MA, Le Roy M, Descatoire V, et al. Plasma membrane cytochrome P450 as neoantigens and autoimmune targets in drug-induced hepatitis. J Hepatol. 1997;26(Suppl. 1):23–30.CrossRefGoogle Scholar
  7. 7.
    Castiella A, Zapata E, Lucena MI, et al. Drug-induced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014;6(4):160–8.CrossRefGoogle Scholar
  8. 8.
    Agarwal VK, McHutchison JG, Hoofnagle JH. Important elements for the diagnosis of drug-induced liver injury. Clin Gastroenterol Hepatol. 2010;8:463–70.CrossRefGoogle Scholar
  9. 9.
    Czaja AJ. Drug-induced autoimmune-like hepatitis. Dig Dis Sci. 2011;56:958–76.CrossRefGoogle Scholar
  10. 10.
    Paiva LA, Wright PJ, Koff RS. Long-term hepatic memory for hypersensitivity to nitrofurantoin. Am J Gastroenterol. 1992;87(7):891–3.PubMedGoogle Scholar
  11. 11.
    Lucena MI, Kaplowitz N, Hallal H, et al. Recurrent Drug-Induced Liver Injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J Hepatol. 2011;55:820–7.CrossRefGoogle Scholar
  12. 12.
    Chalasani N, Bjornsson E. Risk factors for idiosyncratic drug-induced liver injury. Gastroenterology. 2010;138:2246–59.CrossRefGoogle Scholar
  13. 13.
    Elkayam O, Yaron M, Caspi D. Minocycline-induced autoimmune syndromes: an overview. Semin Arthritis Rheum. 1999;28(6):392–7.CrossRefGoogle Scholar
  14. 14.
    Stricker BH, Blok AP, Claas FH, et al. Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases. Hepatology. 1988;8(3):599–606.CrossRefGoogle Scholar
  15. 15.
    Bjornsson E, Talwalkar J, Treeprasertsuk S, et al. Drug-induced autoimmune hepatitis: clinical characteristics and prognosis. Hepatology. 2010;51:2040–8.CrossRefGoogle Scholar
  16. 16.
    de Boer YS, Kosinski AS, Urban TJ, et al. Features of autoimmune hepatitis in patients with drug-induced liver injury. Clin Gastroenterol Hepatol. 2017;15:103–12.CrossRefGoogle Scholar
  17. 17.
    Hisamochi A, Kage M, Ide T, et al. An analysis of drug-induced liver injury, which showed histological findings similar to autoimmune hepatitis. J Gastroenterol. 2016;51:597–607.CrossRefGoogle Scholar
  18. 18.
    Suzuki A, Brunt EM, Kleiner DE, et al. The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury. Hepatology. 2011;54:931–9.CrossRefGoogle Scholar
  19. 19.
    Kessler WR, Cummings OW, Eckert G, et al. Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis. Clin Gastroenterol Hepatol. 2004;2:625–31.CrossRefGoogle Scholar
  20. 20.
    Lohse AW, Chazouilleres O, Dalekos G, Drenth J, Heneghan M, Hofer H, Lammert F, Lenzi M. EASL clinical practice guidelines: autoimmune hepatitis. J Hepatol. 2015;63(4):971–1004.CrossRefGoogle Scholar
  21. 21.
    Bhagwat AG, Warren RE. Hepatic reaction to nitrofurantoin. Lancet. 1969;2(7634):1369.CrossRefGoogle Scholar
  22. 22.
    Chalasani N, Fontana RJ, Bonkovsky HL, et al. Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology. 2008;135:1924–34.CrossRefGoogle Scholar
  23. 23.
    Appleyard S, Saraswati R, Gorard DA. Autoimmune hepatitis triggered by nitrofurantoin: a case series. J Med Case Rep. 2010;4:311.CrossRefGoogle Scholar
  24. 24.
    Ford TJ, Dillon JF. Minocycline hepatitis. Eur J Gastroenterol Hepatol. 2008;8:796–9.CrossRefGoogle Scholar
  25. 25.
    Ramakrishna J, Johnson AR, Banner BF. Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis. J Clin Gastroenterol. 2009;43(8):787–90.CrossRefGoogle Scholar
  26. 26.
  27. 27.
    Farmer JA, Torre-Amione G. Comparative tolerability of the HMG-CoA reductase inhibitors. Drug Saf. 2000;23(3):197–213.CrossRefGoogle Scholar
  28. 28.
    Russo MW, Hoofnagle JH, Jiezhun G, et al. Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network. Hepatology. 2014;60(2):679–86.CrossRefGoogle Scholar
  29. 29.
    Ghabril M, Bonkovsky HL, Kum C, et al. Liver injury from tumor necrosis factor-α antagonists: analysis of thirty-four cases. Clin Gastroenterol Hepatol. 2013;11:558–64.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of HepatologyCarolinas Medical Center-Atrium HealthCharlotteUSA

Personalised recommendations