Targeting Cyclic Dinucleotide Signaling with Small Molecules

  • Herman O. SintimEmail author
  • Clement Opoku-Temeng


Cyclic dinucleotides (CDNs) are now established as master regulators of bacterial physiology (cyclic di-GMP, cyclic di-AMP, 3′3′-cGAMP) and immune function (bacterial cyclic dinucleotides and host’s 2′3′-cGAMP). Metabolic enzymes that modulate the concentrations of CDNs and/or effector proteins or nucleic acids that bind to these second messengers are potential therapeutic targets for the development of antibiofilm, antivirulence, and immunomodulatory agents. Here, we discuss some of the recent advances in the development of small molecule regulators of cyclic di-GMP, cyclic di-AMP, and cGAMP signaling.


Cyclic di-GMP inhibitors Cyclic di-AMP inhibitors cGAMP inhibitors 



We thank the NSF for funding our cyclic dinucleotide research.


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Authors and Affiliations

  1. 1.Chemistry DepartmentPurdue UniversityWest LafayetteUSA
  2. 2.Purdue Institute for Drug DiscoveryPurdue UniversityWest LafayetteUSA
  3. 3.Purdue Institute of Inflammation, Immunology and Infectious DiseasePurdue UniversityWest LafayetteUSA

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