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Asthma

  • Amy A. EapenEmail author
  • Amal Assa’ad
Chapter
  • 52 Downloads

Abstract

Food allergy is growing in prevalence across the nation. Asthma exists as a comorbidity in a large proportion of children with food allergy as part of the atopic march. Food allergy alone can pose its challenges in diagnosis and management and can change based on ethnicity and gender. With the addition of asthma, children can be predisposed to increased risk of severe or fatal reactions. Care must thus be taken to ensure that symptoms of asthma are recognized and diagnosed early on, and appropriate treatment is administered. In this chapter, we give an overview of both food allergy and asthma, their clinical presentation and pathophysiology, presence as a comorbidity, diagnosis and management. We also address the increased risks that food allergy poses in children with asthma and how to best manage these risks.

Keywords

Food allergy Asthma Fatal food reactions Pathophysiology of asthma Atopic march Biologics Oral immunotherapy and asthma 

Abbreviations

ACT

Asthma control test

EAACI

European Academy of Allergy and Clinical Immunology

ED

Emergency department

FAAP

Food Action Allergy Plan

FARE

Food Allergy Research and Education

FEV1

Forced expiratory volume in 1 second

FVC

Forced vital capacity

ICU

Intensive care unit

NCHS

National Center for Health Statistics

NHANES

National Health and Nutrition Examination Survey

NHIS

National Health Interview Survey

OFC

Oral food challenge

OIT

Oral immunotherapy

References

  1. 1.
    Gupta R, Holdford D, Bilaver L, Dyer A, Holl JL, Meltzer D. The economic impact of childhood food allergy in the United States. JAMA Pediatr. 2013;167(11):1026–31.CrossRefGoogle Scholar
  2. 2.
    Allen KJ, Koplin JJ. The epidemiology of IgE-mediated food allergy and anaphylaxis. Immunol Allergy Clin N Am. 2012;32(1):35–50.CrossRefGoogle Scholar
  3. 3.
    Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jiang JL, Davis MM, et al. The public health impact of parent-reported childhood food allergies in the United States. Pediatrics. 2018;142(6):e20181235.PubMedPubMedCentralGoogle Scholar
  4. 4.
    Black LI, Benson V. Tables of Summary Health Statistics for U.S. Children: 2016 National Health Interview Survey, C-2a, 2018. Available from: https://ftp.cdc.gov/pub/Health_Statistics/NCHS/NHIS/SHS/2016_SHS_Table_C-2.pdf
  5. 5.
    Keet CA, Savage JH, Seopaul S, Peng RD, Wood RA, Matsui EC. Temporal trends and racial/ethnic disparity in self-reported pediatric food allergy in the United States. Ann Allergy Asthma Immunol. 2014;112(3):222–9.e3.PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Mahdavinia M, Fox SR, Smith BM, James C, Palmisano EL, Mohammed A, et al. Racial differences in food allergy phenotype and health care utilization among US children. J Allergy Clin Immunol Pract. 2017;5(2):352–7.e1.PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    Koplin JJ, Allen KJ, Gurrin LC, Peters RL, Lowe AJ, Tang ML, et al. The impact of family history of allergy on risk of food allergy: a population-based study of infants. Int J Environ Res Public Health. 2013;10(11):5364–77.PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol. 2001;107(1):191–3.PubMedCrossRefGoogle Scholar
  9. 9.
    Collaborators GBDM. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084–150.CrossRefGoogle Scholar
  10. 10.
    Jang J, Gary Chan KC, Huang H, Sullivan SD. Trends in cost and outcomes among adult and pediatric patients with asthma: 2000-2009. Ann Allergy Asthma Immunol. 2013;111(6):516–22.PubMedCrossRefGoogle Scholar
  11. 11.
    Ferrante G, La Grutta S. The burden of pediatric asthma. Front Pediatr. 2018;6:186.PubMedPubMedCentralCrossRefGoogle Scholar
  12. 12.
    Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391(10122):783–800.PubMedCrossRefGoogle Scholar
  13. 13.
    Akinbami LJ, Moorman JE, Simon AE, Schoendorf KC. Trends in racial disparities for asthma outcomes among children 0 to 17 years, 2001–2010. J Allergy Clin Immunol. 2014;134(3):547–53.e5.PubMedPubMedCentralCrossRefGoogle Scholar
  14. 14.
    Ross MK, Romero T, Sim MS, Szilagyi PG. Obese- and allergic-related asthma phenotypes among children across the United States. J Asthma. 2018;56:1–10.PubMedCrossRefGoogle Scholar
  15. 15.
    Sismanopoulos N, Delivanis DA, Mavrommati D, Hatziagelaki E, Conti P, Theoharides TC. Do mast cells link obesity and asthma? Allergy. 2013;68(1):8–15.PubMedCrossRefGoogle Scholar
  16. 16.
    Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014;69(8):1008–25.PubMedCrossRefGoogle Scholar
  17. 17.
    Jackson DJ. Early-life viral infections and the development of asthma: a target for asthma prevention? Curr Opin Allergy Clin Immunol. 2014;14(2):131–6.PubMedPubMedCentralCrossRefGoogle Scholar
  18. 18.
    Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995;332(3):133–8.PubMedCrossRefGoogle Scholar
  19. 19.
    Hovland V, Riiser A, Mowinckel P, Carlsen KH, Lodrup Carlsen KC. The significance of early recurrent wheeze for asthma outcomes in late childhood. Eur Respir J. 2013;41(4):838–45.PubMedCrossRefGoogle Scholar
  20. 20.
    Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert TW, et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med. 2005;172(10):1253–8.PubMedPubMedCentralCrossRefGoogle Scholar
  21. 21.
    Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet. 2008;372(9643):1058–64.PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Muraro A, Roberts G, Worm M, Bilo MB, Brockow K, Fernandez Rivas M, et al. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy. 2014;69(8):1026–45.PubMedCrossRefGoogle Scholar
  23. 23.
    Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, et al. Second symposium on the definition and management of anaphylaxis: summary report – second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med. 2006;47(4):373–80.PubMedCrossRefGoogle Scholar
  24. 24.
    Longo G, Berti I, Burks AW, Krauss B, Barbi E. IgE-mediated food allergy in children. Lancet. 2013;382(9905):1656–64.PubMedCrossRefGoogle Scholar
  25. 25.
    Shaker M. New insights into the allergic march. Curr Opin Pediatr. 2014;26(4):516–20.PubMedCrossRefGoogle Scholar
  26. 26.
    Flohr C, Perkin M, Logan K, Marrs T, Radulovic S, Campbell LE, et al. Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants. J Invest Dermatol. 2014;134(2):345–50.PubMedCrossRefGoogle Scholar
  27. 27.
    Dharmage SC, Lowe AJ, Matheson MC, Burgess JA, Allen KJ, Abramson MJ. Atopic dermatitis and the atopic march revisited. Allergy. 2014;69(1):17–27.PubMedCrossRefGoogle Scholar
  28. 28.
    Bantz SK, Zhu Z, Zheng T. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. J Clin Cell Immunol. 2014;5(2):67–73.Google Scholar
  29. 29.
    Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, et al. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010;126(6):1105–18.PubMedPubMedCentralCrossRefGoogle Scholar
  30. 30.
    Schroeder A, Kumar R, Pongracic JA, Sullivan CL, Caruso DM, Costello J, et al. Food allergy is associated with an increased risk of asthma. Clin Exp Allergy. 2009;39(2):261–70.PubMedPubMedCentralCrossRefGoogle Scholar
  31. 31.
    Anagnostou A. Anaphylaxis in children: epidemiology risk factors and management. Curr Pediatr Rev. 2018;14(3):180–6.PubMedCrossRefGoogle Scholar
  32. 32.
    Friedlander JL, Sheehan WJ, Baxi SN, Kopel LS, Gaffin JM, Ozonoff A, et al. Food allergy and increased asthma morbidity in a School-based inner-city Asthma Study. J Allergy Clin Immunol Pract. 2013;1(5):479–84.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Calvani M, Cardinale F, Martelli A, Muraro A, Pucci N, Savino F, et al. Risk factors for severe pediatric food anaphylaxis in Italy. Pediatr Allergy Immunol. 2011;22(8):813–9.PubMedCrossRefGoogle Scholar
  34. 34.
    Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327(6):380–4.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    Simons FE. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004;113(5):837–44.PubMedGoogle Scholar
  36. 36.
    Zicari AM, Indinnimeo L, De Castro G, Zappala D, Tancredi G, Bonci E, et al. Food allergy and the development of asthma symptoms. Int J Immunopathol Pharmacol. 2012;25(3):731–40.PubMedCrossRefGoogle Scholar
  37. 37.
    Savage J, Johns CB. Food allergy: epidemiology and natural history. Immunol Allergy Clin North Am. 2015;35(1):45–59.PubMedCrossRefGoogle Scholar
  38. 38.
    Jat KR. Spirometry in children. Prim Care Respir J. 2013;22(2):221–9.PubMedPubMedCentralCrossRefGoogle Scholar
  39. 39.
    Krogulska A, Dynowski J, Jedrzejczyk M, Sardecka I, Malachowska B, Wasowska-Krolikowska K. The impact of food allergens on airway responsiveness in schoolchildren with asthma: a DBPCFC study. Pediatr Pulmonol. 2016;51(8):787–95.PubMedCrossRefGoogle Scholar
  40. 40.
    Vazquez-Ortiz M, Alvaro M, Piquer M, Giner MT, Dominguez O, Lozano J, et al. Life-threatening anaphylaxis to egg and milk oral immunotherapy in asthmatic teenagers. Ann Allergy Asthma Immunol. 2014;113(4):482–4.PubMedCrossRefGoogle Scholar
  41. 41.
    Banasiak NC. Implementation of the asthma control test in primary care to improve patient outcomes. J Pediatr Health Care. 2018;32(6):591–9.PubMedCrossRefGoogle Scholar
  42. 42.
    Food Allergy & Anaphylaxis Emergency Care Plan. Food Allergy Research and Education (FARE). https://www.foodallergy.org/life-with-food-allergies/food-allergy-anaphylaxis-emergency-care-plan. Accessed May 2019.
  43. 43.
    Walkner M, Warren C, Gupta RS. Quality of life in food Allergy patients and their families. Pediatr Clin N Am. 2015;62(6):1453–61.CrossRefGoogle Scholar
  44. 44.
    Eldredge C, Patterson L, White B, Schellhase K. Assessing the readiness of a school system to adopt food allergy management guidelines. Wis Med J. 2014;113(4):155–61.Google Scholar
  45. 45.
    Crenesse D, Berlioz M, Bourrier T, Albertini M. Spirometry in children aged 3 to 5 years: reliability of forced expiratory maneuvers. Pediatr Pulmonol. 2001;32(1):56–61.PubMedCrossRefGoogle Scholar
  46. 46.
    Santos AF, Gomes-Belo J, Hannachi F, Swan K. Advances in food allergy diagnosis. Curr Pediatr Rev. 2018;14(3):139–49.PubMedCrossRefGoogle Scholar
  47. 47.
    Parrish CP, Har D, Andrew Bird J. Current status of potential therapies for IgE-mediated food allergy. Curr Allergy Asthma Rep. 2018;18(3):18.PubMedCrossRefGoogle Scholar
  48. 48.
    Varshney P, Steele PH, Vickery BP, Bird JA, Thyagarajan A, Scurlock AM, et al. Adverse reactions during peanut oral immunotherapy home dosing. J Allergy Clin Immunol. 2009;124(6):1351–2.PubMedPubMedCentralCrossRefGoogle Scholar
  49. 49.
    Elizur A, Goldberg MR, Levy MB, Nachshon L, Katz Y. Oral immunotherapy in cow’s milk allergic patients: course and long-term outcome according to asthma status. Ann Allergy Asthma Immunol. 2015;114(3):240–4.e1.PubMedCrossRefGoogle Scholar
  50. 50.
    Schneider LC, Rachid R, LeBovidge J, Blood E, Mittal M, Umetsu DT. A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol. 2013;132(6):1368–74.PubMedPubMedCentralCrossRefGoogle Scholar
  51. 51.
    Dantzer JA, Wood RA. The use of omalizumab in allergen immunotherapy. Clin Exp Allergy. 2018;48(3):232–40.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Allergy and ImmunologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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