Cancer Stem Cells in Oral Carcinoma

  • Miguel Ángel González-MolesEmail author
  • Lucía González-Ruiz
  • Pablo Ramos-García
Part of the Textbooks in Contemporary Dentistry book series (TECD)


A new paradigm has recently been developed concerning the etiology of oral cancer. It proposes that solely stem cells, a small proportion of cells, are able to be transformed into a tumor, maintain its growth, and contribute to metastatic spread. This new perspective on oral oncogenesis may have major repercussions for the treatment of oral squamous cell carcinomas. This chapter reviews the most important concepts related to stem cells and cancer stem cells, reporting information on their physiology, detection, and implications for tumor onset and therapeutic targeting.


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Readings Especially Recommended

  1. González-Moles MA, Scully C, Ruiz-Ávila I, Plaza-Campillo JJ. The cancer stem cell hypothesis applied to oral carcinoma. Oral Oncol. 2013;49(8):738–46.CrossRefGoogle Scholar
  2. Reid PA, Wilson P, Li Y, Marcu LG, Bezak E. Current understanding of cancer stem cells: review of their radiobiology and role in head and neck cancers. Head Neck. 2017;39(9):1920–32. Epub 2017 Jun 23.CrossRefPubMedGoogle Scholar
  3. Méry B, Guy JB, Espenel S, Wozny AS, Simonet S, Vallard A, Alphonse G, Ardail D, Rodriguez-Lafrasse C, Magné N. Targeting head and neck tumoral stem cells: from biological aspects to therapeutic perspectives. World J Stem Cells. 2016;8(1):13 21.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Miguel Ángel González-Moles
    • 1
    Email author
  • Lucía González-Ruiz
    • 2
  • Pablo Ramos-García
    • 1
  1. 1.School of DentistryUniversity of GranadaGranadaSpain
  2. 2.Dermatology ServiceCiudad Real General University HospitalCiudad RealSpain

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