Inter-fractional Respiratory Motion Modelling from Abdominal Ultrasound: A Feasibility Study

  • Alina GigerEmail author
  • Christoph Jud
  • Damien Nguyen
  • Miriam Krieger
  • Ye Zhang
  • Antony J. Lomax
  • Oliver Bieri
  • Rares Salomir
  • Philippe C. Cattin
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11843)


Motion management strategies are crucial for radiotherapy of mobile tumours in order to ensure proper target coverage, save organs at risk and prevent interplay effects. We present a feasibility study for an inter-fractional, patient-specific motion model targeted at active beam scanning proton therapy. The model is designed to predict dense lung motion information from 2D abdominal ultrasound images. In a pretreatment phase, simultaneous ultrasound and magnetic resonance imaging are used to build a regression model. During dose delivery, abdominal ultrasound imaging serves as a surrogate for lung motion prediction. We investigated the performance of the motion model on five volunteer datasets. In two cases, the ultrasound probe was replaced after the volunteer has stood up between two imaging sessions. The overall mean prediction error is 2.9 mm and 3.4 mm after repositioning and therefore within a clinically acceptable range. These results suggest that the ultrasound-based regression model is a promising approach for inter-fractional motion management in radiotherapy.


Motion prediction Ultrasound 4D MRI Radiotherapy 



We thank Pauline Guillemin from the University of Geneva, Switzerland, for her indispensable support with the data acquisition. This work was supported by the Swiss National Science Foundation, SNSF (320030_163330/1) and the GPU Grant Program of NVIDIA (Nvidia Corporation, Santa Clara, California, USA).


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Center for medical Image Analysis and NavigationUniversity of BaselAllschwilSwitzerland
  2. 2.Department of Biomedical EngineeringUniversity of BaselAllschwilSwitzerland
  3. 3.Department of Radiology, Division of Radiological PhysicsUniversity Hospital BaselBaselSwitzerland
  4. 4.Center for Proton Therapy, Paul Scherrer Institute (PSI)Villigen PSISwitzerland
  5. 5.Department of PhysicsETH ZurichZurichSwitzerland
  6. 6.Image Guided Interventions LaboratoryUniversity of GenevaGenevaSwitzerland

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