This chapter covers crucial aspects of the formulation of pharmaceutical suspensions. Properties relevant to suspension stability and drug delivery are discussed, including particle settling, flocculation, particle aggregation, viscosity, zeta potential, and Ostwald ripening are discussed. Methods of particle size reduction are introduced, including those to produce nanoparticles. An extensive discussion of relevant excipients is also included.
This is a preview of subscription content, log in to check access.
Suggested readings for the student include the following texts:Google Scholar
Iyer AK, et al. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today. 2006;11(17):812–8.CrossRefGoogle Scholar
Jermain SV, Brough C, Williams RO III. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery–an update. Int J Pharm. 2018;535(1–2):379–92.CrossRefGoogle Scholar
Leleux J, Williams RO III. Recent advances in mechanical reduction methods: particulate systems. Drug Dev Ind Pharm. 2014;40(3):289–300.CrossRefGoogle Scholar
Wong J, et al. Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects. Adv Drug Deliv Rev. 2008;60:939–54.CrossRefGoogle Scholar