Nasal Drug Delivery

  • Ashlee D. Brunaugh
  • Hugh D. C. Smyth
  • Robert O. Williams III
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)


This chapter covers the fundamentals of nasal drug delivery. Anatomical barriers to drug delivery, examples and functions of commonly used excipients, and device design are reviewed. Analytical procedures relevant to testing the performance of nasal drug products are also introduced.


Nasal drug delivery Nasal formulations Nasal drug delivery devices Nasal device performance testing Nasal spray 

Further Reading

  1. Suggested readings for the student include the following texts:Google Scholar
  2. 1.
    Arora P, Sharma S, Garg S. Permeability issues in nasal drug delivery. Drug Discov Today. 2002;7(18):967–75.CrossRefGoogle Scholar
  3. 2.
    Djupesland PG. Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review. Drug Deliv Transl Res. 2013;3(1):42–62.CrossRefGoogle Scholar
  4. 3.
    Warnken ZN, Smyth HD, Davis DA, Weitman S, Kuhn JG, Williams RO III. Personalized medicine in nasal delivery: the use of patient-specific administration parameters to improve nasal drug targeting using 3D-printed nasal replica casts. Mol Pharm. 2018;15(4):1392–402.CrossRefGoogle Scholar
  5. 4.
    Warnken Z, Smyth HD, Williams RO. Route-specific challenges in the delivery of poorly water-soluble drugs. In: Formulating poorly water soluble drugs. Cham: Springer; 2016. p. 1–39.Google Scholar
  6. 5.
    Warnken Z, Kim Y, Mansour H, Williams RO III, Smyth HDC. Fundamentals in nasal drug delivery. In: Inhalation aerosols: physical and biological basis for therapy. 3rd ed. Boca Raton: CRC Press; 2019.Google Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Ashlee D. Brunaugh
    • 1
  • Hugh D. C. Smyth
    • 1
  • Robert O. Williams III
    • 1
  1. 1.College of PharmacyThe University of Texas at AustinAustinUSA

Personalised recommendations