Rectal and Vaginal Drug Delivery

  • Ashlee D. Brunaugh
  • Hugh D. C. Smyth
  • Robert O. Williams III
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)


This chapter provides an overview of dosage forms relevant to rectal and vaginal drug delivery. Barriers to drug absorption are discussed and frequently used excipients are covered. The manufacturing and special formulation considerations for drug delivery using suppository formulations are also reviewed.


Rectal drug delivery Vaginal drug delivery Suppositories Vaginal dosage forms Suppository excipients Suppository manufacturing 

Further Reading

  1. Suggested readings for the student include the following texts:Google Scholar
  2. 1.
    Lang B, McGinity JW, Williams RO. Hot melt extrusion—basic principles and pharmaceutical applications. Drug Dev Ind Pharm. 2014;40(9):1133–55.. (see page 1150; “Implants” section)CrossRefGoogle Scholar
  3. 2.
    Shin S, Byun S. Controlled release of ethinylestradiol from ethylene-vinyl acetate membrane. Int J Pharm. 1996;137(21):95–102.CrossRefGoogle Scholar
  4. 3.
    Anderson GD, Saneto RP. Current oral and non-oral routes of antiepileptic drug delivery. Adv Drug Deliv Rev. 2012;64(10):911–8.CrossRefGoogle Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Ashlee D. Brunaugh
    • 1
  • Hugh D. C. Smyth
    • 1
  • Robert O. Williams III
    • 1
  1. 1.College of PharmacyThe University of Texas at AustinAustinUSA

Personalised recommendations