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Nanovaccines pp 233-265 | Cite as

Liposome-Based Nanovaccines

  • Sergio Rosales-Mendoza
  • Omar González-Ortega
Chapter

Abstract

Liposomes are nanosized lipid particles that have become attractive vaccine delivery vehicles given their properties that include versatility for functionalization, controlled charge, high encapsulation capacity, high surface, and efficient cellular uptake. This chapter contains a description of the liposomes preparation techniques and their application to develop mucosal nanovaccines. The analysis of the current literature reveals that there are many attractive vaccine candidates based on this technology, although the majority have been evaluated in parenteral schemes. The mucosal formulations tested thus far are against parasitic, bacterial, and viral diseases. A cancer vaccine was also developed. The formulations have been assessed in test animals and administered intranasally, orally, sublingually, and by the airways. Immunogenicity assessment in preclinical studies supports the use of liposomes to enhance cellular and humoral responses. Therefore, liposomes are effective nanoparticles and the outstanding findings from the preclinical evaluation of many mucosal vaccine candidates indicate that there is a good prospect for the initiation of clinical trials in the coming years. The challenges for this field comprise expanding the assessment of mucosal formulations, achieving high stability in the formulation, and scale-up production.

Keywords

Cross-presentation Thin film hydration Unilamellar vesicles Multilamellar vesicles 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sergio Rosales-Mendoza
    • 1
  • Omar González-Ortega
    • 2
  1. 1.Facultad de Ciencias Químicas, Centro de Investigación en Ciencias de la Salud y BiomedicinaUniversidad Autónoma de San Luis PotosíSan Luis PotosíMexico
  2. 2.Facultad de Ciencias QuímicasUniversidad Autónoma de San Luis Potosí San Luis PotosíMexico

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