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Chapter 25: Peptide Drug/Device Combinations

  • Shahid UddinEmail author
Chapter
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Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 35)

Abstract

Peptides play an important role in human physiology, and peptide deficiencies or dysfunction can lead to disease or illness. Therefore, the role that peptides play in disease treatment goes back many years, starting with the use of insulin in patients with type 1 diabetes almost a century ago. The range of targets available for peptide therapeutics and the limitations associated with peptide delivery and therapeutic effect require consideration. This chapter will review the history of the use of peptides as therapeutics, address some challenges in clinical use, and touch on major advances in the use of peptides as drugs. It will also address issues related with formulation and formulation development; peptide bond formation methods; the use of excipients; the synthesis of peptides, as well as aggregation, separation, and purification; and characterisation and stability testing. It further explores the pharmacokinetics of peptides and various routes of drug delivery and challenges related to peptide delivery.

Keywords

Peptides Formulation Excipients Aggregation Synthesis Separation Purification Characterisation Stability Pharmacokinetics Delivery Delivery systems Enteral delivery Parenteral Intranasal Lipohypertrophy Devices 

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Copyright information

© American Association of Pharmaceutical Scientists 2020

Authors and Affiliations

  1. 1.ImmunocoreOxfordshireUK

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