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Cultivating Research Grade Cannabis for the Development of Phytopharmaceuticals

  • Hemant Lata
  • Suman Chandra
  • Esther E. Uchendu
  • Ikhlas A. Khan
  • Mahmoud A. ElSohlyEmail author
Chapter

Abstract

Cannabis has been used as medicine since ancient times in different forms. With over 500 known constituents, of which cannabinoids are the most important class (120 known). Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) are the two major natural cannabinoids having very different pharmacological profiles with tremendous therapeutic potential. After the discovery of Δ9-THC, the main psychoactive compound in cannabis, research had been revolving around Δ9-THC and its derivatives. Cannabidiol, a non-psychoactive compound which was discovered before Δ9-THC did not receive much attention for a long time. However, in last few years, research has intensified on CBD or CBD rich cannabis varieties due to its therapeutic potential in the treatment of a variety of ailments including childhood epilepsy (Dravet syndrome) and other disorders. In this chapter, we address cannabis botany, chemistry, its indoor and outdoor cultivation, harvesting, processing and its current status as a botanical drug.

Keywords

Cannabis THC CBD Botanical drug Epilepsy 

Notes

Acknowledgments

This work was supported in part by the National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services, USA, under the contract no. N01DA-15-7793.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Hemant Lata
    • 1
  • Suman Chandra
    • 1
  • Esther E. Uchendu
    • 1
    • 2
  • Ikhlas A. Khan
    • 1
    • 3
  • Mahmoud A. ElSohly
    • 1
    • 4
    Email author
  1. 1.National Center for Natural Products Research, School of PharmacyUniversity of MississippiUniversityUSA
  2. 2.Faculty of Agriculture, Department of AgronomyUniversity of IbadanIbadanNigeria
  3. 3.Department of Biomolecular Sciences, School of PharmacyUniversity of MississippiUniversityUSA
  4. 4.Department of Pharmaceutics and Drug Delivery, School of PharmacyUniversity of MississippiUniversityUSA

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