Nepal: A Global Hotspot for Medicinal Orchids

  • Brajesh Nanda VaidyaEmail author


Floristic diversity of family Orchidaceae in Nepal (area 147,181 sq. km) is impressive, as 517 species under 105 genera have been reported so far. Orchidaceae is one of the largest families in plant kingdom with abundant scientific studies carried out on their phytochemistry, and available bioactive compounds but with insufficient potential medicinal research and applications. Since the ancient Vedic period dating back to 2500 BCE, orchids have been mentioned widely for their medicinal use in traditional medical system of Ayurveda. Ancient scripts like Rig-Veda contain the preparation methods of formulations using orchids in combination with other herbs and their healing powers. Some of the compounds identified for their bioactivity are alkaloids, anthraquinones, cardiac glycosides, flavonoids, glycosides, phlobatanins, quercetin, reducing sugars, saponins, steroids, and terpenoids. There are numerous studies on ethnobotanical uses of orchids found in Nepal. In this chapter, medicinal properties of a total of 130 species are discussed; several of these species have been tested for their chemical constituents, in vitro properties and in vivo clinical efficacy. Unfortunately, orchids in their natural habitats are disappearing at an alarming rate. There is an immediate need to conserve orchids in their natural habitats at local, national, and international levels. This situation coupled with climate change poses grave challenges to the efforts to understand their medicinal properties.


Medicinal orchids Nepal Himalayas Ayurveda Conservation 



Thank you to Dr. Nirmal Joshee, for providing constant support and mentorship, and helping me finish this chapter, the idea of which originated 20 years ago. Thanks to late Professor Michael Wirth, from my undergraduate years at New England College, Henniker, New Hampshire, who introduced me to the wonderful world of orchids.


  1. Acharya KP (2018) Orchids of Nepal checklist. Accessed 9 March 2018
  2. Acharya KP, Rokaya MB (2010) Medicinal orchids of Nepal: are they well protected? Our Nat 8:82–91CrossRefGoogle Scholar
  3. Ahmed F, Sayeed A, Islam A et al (2001) Characterization and in vitro antimicrobial activity of 17–hydroxy-14, 20-epoxy-1-oxo-[22R]-3-[O-d-glucopyranosyl]-5, 24-withadienolide from Vanda Roxburghii. Br Sci 1:324–326Google Scholar
  4. Anonymous (1983) Nepali brihat sabdakosh. Royal Nepal Academy, KathmanduGoogle Scholar
  5. Arditti J (1992) Fundamentals of orchid biology. Wiley, New YorkGoogle Scholar
  6. Arditti J (1993) Micropropagation of orchids. Wiley, New YorkGoogle Scholar
  7. Arora M, Mahajan A, Sembi J (2017) A review of phytochemical and pharmacological potential of family Orchidaceae. Intl Res J Pharm 8:9–24CrossRefGoogle Scholar
  8. ASP (2013) Dynamic changes of main active ingredients in A. roxburghii (wall.) Lindl. and A. formosanus in different growth stagesGoogle Scholar
  9. Baas P, Veldkamp JF (2013) Dutch pre-colonial botany and Rumphius’s Ambonese herbal. Allertonia 13:9–19Google Scholar
  10. Bailes (1985) Orchids of Nepal: the conservation and development of natural resources. Advisory report and recommendation. RBG, KewGoogle Scholar
  11. Balami NP (2004) Ethnomedicinal uses of plants among the Newar community of Pharping village of Kathmandu district. Nepal Tribhuvan Univ J 24:13–19CrossRefGoogle Scholar
  12. Banarji ML (1978) Orchids of Nepal. Today and Tomorrow’s Publisher, New DelhiGoogle Scholar
  13. Banerji ML, Pradhan P (1984) The orchids of Nepal Himalaya. J Cramer, GermanyGoogle Scholar
  14. Bao XS, Shun QS, Chen LZ (2001) The medicinal plants of Dendrobium (Shi-Hu) in China, a coloured atlas. Fudan Uni Press, Shanghai. (in Chinese)Google Scholar
  15. Baral SR, Kurmi PP (2006) A compendium of medicinal plants of Nepal. Mass Printing Press, Kathmandu, NepalGoogle Scholar
  16. Barnette M (1992) A garden of words. Times Book, New YorkGoogle Scholar
  17. Basu K, Das GB, Bhattacharya SK et al (1971) Anti-inflammatory principles of Vanda roxburghii. Curr Sci 40:86–87Google Scholar
  18. Berliocchi L (2004) The orchid in lore and legend. Timber Press, Portland, ORGoogle Scholar
  19. Bhandari SR, Kapadi AH, Mujumder PL et al (1985) Nudol, a phenanthrene of the orchids Eulophia nuda, Eria carinata and Eria stricta. Phytochemistry 24(4):801–804CrossRefGoogle Scholar
  20. Bhatnagar M, Ghosal S (2018) Antibacterial and antimycobacterial activity of medicinal orchid of Arunachal Pradesh. Int J Pharm Sci Res 9(2):712–717. Scholar
  21. Bhatnagar M, Sarkar N, Gandharv N et al (2017) Evaluation of antimycobacterial, leishmanicidal and antibacterial activity of three medicinal orchids of Arunachal Pradesh, India. BMC Complem Alternative Med 17:379CrossRefGoogle Scholar
  22. Bhattacharjee B, Islam SMS (2015) Assessment of antibacterial and antifungal activities of the extracts of Rhyncostylis retusa Blume—A medicinal orchid. World J Pharm Pharm Sci 4(2):74–87Google Scholar
  23. Bi ZM, Wang ZT et al (2003) Studies on the chemical constituents of Dendrobium fimbriatum. Yao Xue Xue Bao 38:526–529PubMedPubMedCentralGoogle Scholar
  24. Biswas S, Pardeshi R, Reddy ND et al (2016) Bulbophyllum sterile petroleum ether fraction induces apoptosis in vitro and ameliorates tumor progression in vivo. Biomed Pharmacother 84:1419–1427PubMedCrossRefPubMedCentralGoogle Scholar
  25. Bulpitt CJ (2005) The use and misuse of orchids in medicine. Q J Med 98:625–631CrossRefGoogle Scholar
  26. Bulpitt CJ, Li Y, Bulpitt PF et al (2007) The use of orchids in Chinese medicine. J Royal Soc Med 100:558–563CrossRefGoogle Scholar
  27. Campbell MW (1983) Plant propagation for reforestation in Nepal, Rev. Ed, Nepal-Australia Forestry Project, Dept. of Forestry, Australian Nat Uni, CanberraGoogle Scholar
  28. Chand MB, Paudel MR, Pant B (2016) The antioxidant activity of selected wild orchids of Nepal. J Coastal Life Med 4(9):731–736CrossRefGoogle Scholar
  29. Chaudhary RP (1998) Biodiversity in Nepal: status and conservation. Craftsman Press, BangkokGoogle Scholar
  30. Chaudhary R, Uprety Y, Rimal S (2015) Deforestation in Nepal: Causes, consequences and responses. Biological and Environmental hazards, risks and disasters. In: Hazards and disaster series. pp 335–372Google Scholar
  31. Chauhan NS (1990) Medicinal orchids of Himachal Pradesh. J Orchid Soc India 4:99–105Google Scholar
  32. Chauhan NS (1999) Medicinal and aromatic plants of Himachal Pradesh. Indus Publishing Company, New DelhiGoogle Scholar
  33. Chen Y, Xu J, Yu H et al (2007a) 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene, a new phenanthrene from Bulbophyllum odoratissimum. J Korean Chem Soc 51:352CrossRefGoogle Scholar
  34. Chen Y, Xu J, Yut H et al (2007b) Bulbophyllum odoratissimum 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene. J Korean Chem Soc 51:352–355CrossRefGoogle Scholar
  35. China Tea Review (2012) Herbal tea: dendrobium flower tea. Accessed 24 Sept 2018
  36. Chopra RN, Nair SL, Chopra IC (1956) Glossary of Indian medicinal plants. PID, New DelhiGoogle Scholar
  37. da Silva JAT, Acharya KP (2014) In Vitro propagation of Nepalese orchids: a review. J Hort Res 22(2):47–52Google Scholar
  38. Darwin C (1862) On the various contrivances by which British and foreign orchids are fertilised by insects. John Murray, LondonGoogle Scholar
  39. Dash B, Sharma RK (2015) Caraka Samhita. Vol. 1. Chaukhamba Sanskrit Series, IndiaGoogle Scholar
  40. Dash PK, Sahoo S, Subhasisa B (2008) Ethnobotanical studies on orchids of Niyamgiri Hill ranges, Orissa, India. Ethnobot Leaflets 12:70–78Google Scholar
  41. DFRS (1999) Forest and shrub cover of Nepal 1994 (1989–1996). Dept of Forest Research and Survey, Kathmandu, NepalGoogle Scholar
  42. DPR (2001) Flowering plants of Nepal (Phanerogams), HMG Ministry of Forests and Soil Conservation. Dept Plant Res, Kathmandu, NepalGoogle Scholar
  43. Dresseler RL (1982) The orchids: natural history and classification. Harvard University Press, BostonGoogle Scholar
  44. Fan C, Wang W, Wang Y et al (2001) Chemical constituents from Dendrobium densiflorum. Phytochemistry 57:1255–1258PubMedCrossRefPubMedCentralGoogle Scholar
  45. Garha M (2017) Health care in Nepal: an observational perspective. J Nursing Edu Practice 7(1):114–117Google Scholar
  46. Gewali MB (2008) Aspects of traditional medicine in Nepal. Institute of National Medicine. Univ of Toyama, Toyama, JapanGoogle Scholar
  47. Giri D, Tamta S (2010) A general account on traditional medicinal uses of Dactylorhiza hatagirea (D. Don) Soo. NY Sci J 3:78–79Google Scholar
  48. GoN (2008) Stocktaking report on biodiversity: national capacity self-assessment for global environment management. Ministry of Environ, Sci Tech, Kathmandu, NepalGoogle Scholar
  49. Gong YQ, Fan Y, Wu DZ et al (2004) In vivo and in vitro evaluation of erianin, a novel antiangiogenic agent. Eur J Cancer 40:1554–1565PubMedCrossRefPubMedCentralGoogle Scholar
  50. Govaerts R, Bernet P, Kratochvil K et al (2017) World checklist of Orchidaceae. Kew: Royal Botanic Gardens. Accessed 3 Sept 2018
  51. Gutiérrez RMP (2010) Orchids: a review of uses in traditional medicine, its phytochemistry and pharmacology. J Med Plant Res 4(8):592–638Google Scholar
  52. Hamilton FB (1819) An account of the Kingdom of Nepal, and of the territories annexed to this dominion by the house of Gorkha. Archibald Constable and Company, LondonGoogle Scholar
  53. Hamilton FB, Don D (1824) Prodromus Florae Nepalensis. J. Gale, LondonGoogle Scholar
  54. Hara H, Stearn WT, Williams WT et al (1978) An enumeration of the flowering plants of Nepal, vol 1. Trustees of the British Museum (Natural History), LondonGoogle Scholar
  55. He C, Wang C, Guo S, Yang J, Xiao P (2006) A novel flavonoid glucoside from Anoectochilus roxburghii (Wall.) Lindl. J Integr Plant Biol 48:359–363CrossRefGoogle Scholar
  56. Heo JC, Woo SU, Son M et al (2007) Antitumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras dependent pathway. Oncol Rep 8:849–853Google Scholar
  57. Hinsley A, de Boer HJ, Fay MF et al (2017) A review of the trade in orchids and its implications for conservation. Bot J Linn Soc 186:435–455CrossRefGoogle Scholar
  58. Hooker JD (1855) Himalayan journals. Notes of a naturalist. Today and tomorrow’s Publishers, DelhiGoogle Scholar
  59. Hossain MM (2011) Therapeutic orchids: traditional uses and recent advances—an overview. Fitoterapia 82:102–140PubMedCrossRefPubMedCentralGoogle Scholar
  60. Ikeda Y, Nonaka H, Furumai T et al (2005) Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod 68:572–573PubMedCrossRefPubMedCentralGoogle Scholar
  61. Jalal J, Kumar P, Pangtey YPS (2008) Ethnomedicinal orchids of Uttarakhand, Western Himalaya. Ethnobotl Leaf 12:1227–1230Google Scholar
  62. Jana SK, Sinha GP, Chauhan NS (1997) Ethnobotanical aspects of orchids of Sikkim. J Orchid Soc India 11:79–84Google Scholar
  63. Joshi G, Tewari LM, Lohani N et al (2009) Diversity of orchids on Uttarakhand and their conservation strategy with special reference to their medicinal importance. Rep Opinion 1:47–52Google Scholar
  64. Kafle G (2011) An overview of shifting cultivation with reference to Nepal: Review. Intl J Biod Cons 3(5):147–154Google Scholar
  65. Karnick CR (1996) Pharmacology of Ayurvedic medicinal plants, Indian Medical Sciences Series, vol 47. Sri Satguru Publications, Delhi, IndiaGoogle Scholar
  66. Kaushik P (1983) Ecological and anatomical marvels of the Himalayan orchids. Today and Tomorrow’s Printers and Publishers, New DelhiGoogle Scholar
  67. Khasin SM, Rao PRM (1999) Medicinal importance of orchids. The Botanica 49:86–91Google Scholar
  68. Khory N (1982) Materia medica of India and their therapeutics. Neeraj Publishing House, Delhi, IndiaGoogle Scholar
  69. Kirtikar KR, Basu BD (1935) Indian medicinal plants, vol III. Lalit Mohan Basu, AllahabadGoogle Scholar
  70. Kizu H, Kaneko EI, Tomimori T (1999) Studies on Nepalese crude drugs. XXVI. Chemical constituents of Panchaunle, the roots of Dactylorhiza hatagirea D. Don. Chem Pharm Bull 47(11):1618–1625CrossRefGoogle Scholar
  71. Kumar V, Choedon T (2013) Medicinal plant used in the practice of Tibetan medicine. In: Govil GN (ed) Recent progress in medicinal plants, potential and challenges. Stadium Press, USAGoogle Scholar
  72. Kumar PKS, Subramoniam A, Pushpangadan (2000) Aphrodisiac activity of Vanda tessellata (Roxb.) Hook. Ex Don extract in male mice. Indian J Pharm 32:300–304Google Scholar
  73. Lad V (1996) Ayurveda: the science of self-healing. Lotus Press, Santa FeGoogle Scholar
  74. Lam Y, Ng TB, Yao RM et al (2015) Evaluation of chemical constituents and important mechanism of pharmacological biology in Dendrobium plants. Evid Based Compliment Alternative Med 2015:841752. Scholar
  75. Lama YC, Ghimire SK, Aumeeruddy-Thomas Y (2001) Medicinal plants of Dolpo: Amchis’ knowledge and conservation. WWF, Kathmandu, NepalGoogle Scholar
  76. Landon P (1928) Nepal. Constable, LondonGoogle Scholar
  77. Lawler LJ (1984) Ethnobotany of the Orchidaceae. In: Orchid biol rev Perspect iii. Comstock Publ. Associates, Ithaca, NY & London, UK, pp 27–149Google Scholar
  78. Lee YH, Park JD, Baek NI et al (1995) In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med 61:178–180PubMedCrossRefPubMedCentralGoogle Scholar
  79. Li YM, Wang HY, Liu GQ (2001) Erianin induces apoptosis in human leukemia HL-60 cells. Acta Pharm Sin 22:1018–1022Google Scholar
  80. Lin YL, Wang WY, Kuo YH et al (2001) Homocyclotirucallane and two dihydrophenanthrenes from Spiranthes sinensis. Chem Pharm Bull 49(9):1098–1101PubMedCrossRefPubMedCentralGoogle Scholar
  81. Liu MF, Han Y, Xing DM et al (2004) A new stilbenoid from Arundina graminifolia. Asian Nat Prod Res 6(3):229–232CrossRefGoogle Scholar
  82. Liu MF, Ding Y, Zhang DM (2005a) Phenanthrene constituents from rhizome of Arundina graminifolia. Zhongguo Zhong Yao Za Zhi 30(5):353–356PubMedPubMedCentralGoogle Scholar
  83. Liu MF, Han Y, Xing DM et al (2005b) One new benzyldihydrophenanthrene from Arundina graminifolia. Asian Nat Prod Res 7(5):767–770CrossRefGoogle Scholar
  84. Liu H, Feng C-L, Luo Y-B et al (2010) Potential challenges of climate change to orchid conservation in a wild orchid hotspot in southwestern China. Bot Rev 76:174–192CrossRefGoogle Scholar
  85. Long P, Long C (2006) In: Bin X, Zhongming C, Zhongten G (eds) Medicinal orchids in China in ethnobotany and medicinal plants. East-South University Press, NanjingGoogle Scholar
  86. Loukas M, Lanteri A, Ferrauiola J et al (2010) Anatomy in ancient India: a focus on the Susruta Samhita. Rev J Anat 217:646–650CrossRefGoogle Scholar
  87. Lüning B (1964) Studies on Orchidaceae alkaloids I, screening of species for alkoloids 1. Acta Chem Scand 18:1507–1518CrossRefGoogle Scholar
  88. Luning B, Leander KK (1965) Studies on orchidaceous alkaloids III. Acta Chem Scand 19:1607–1611CrossRefGoogle Scholar
  89. Majumder PL, Maiti DC (1988) Flaccidin, a 9,10-dihydrophenanthropyran derivative from the orchid Coelogyne flaccida. Phytochemistry 27(3):899–901. Scholar
  90. Majumder PL, Pal S (1993) Cumulatin and tristin, two bibenzyl derivatives from the orchids Dendrobium cumulatum and Bulbophyllum triste. Phytochemistry 32(6):1561–1565. Scholar
  91. Majumder PL, Sen RC (1991) Bulbophyllanthrone, a phenanthraquinone from Bulbophyllum odoratissimum. Phytochemistry 30:2092–2094. Scholar
  92. Majumder PL, Kar A, Shoolery JN (1985) Bulbophyllanthrin, a phenanthrene of the orchid Bulbophyllum leopardium. Phytochemistry 24(9):2083–2087. Scholar
  93. Majumder PL, Banerjee S, Maiti DC (1995) Stilbenoids from the orchids Agrostophyllum callosum and Coelogyne flaccida. Phytochemistry 39(3):649–653CrossRefGoogle Scholar
  94. Majumder PL, Banerjee S, Sen S (1996) Three stilbenoids from the orchid Agrostophyllum callosum. Phytochemistry 42(3):847–852. Scholar
  95. Majumder P, Roychowdhury M, Chakraborty S (1998) Thunalbene, a stilbene derivative from the orchid Thunia alba. Phytochemistry 49(8):2375–2378CrossRefGoogle Scholar
  96. Majumder PL, Sen S, Banerjee S (1999) Agrostophyllol and isoagrostophyllol, two novel diastereomeric 9,10-dihydrophenanthropyran derivatives from the orchid Agrostophyllum callosum. Tetrahedron 55(21):6691–6702CrossRefGoogle Scholar
  97. Majumder PL, Sen S, Majumder S (2001) Phenanthrene derivatives from the orchid Coelogyne cristata. Phytochemistry 58(4):581–586PubMedCrossRefPubMedCentralGoogle Scholar
  98. Malla SB, Shakya PR (1984) Medicinal plants of Nepal. In: Majupuria TC (ed) Nepal Nature’s paradise. White Lotus, Bangkok, pp 261–297Google Scholar
  99. Manandhar (1993) Ethnobotanical notes on folk lore remedies of Baglung district, Nepal. Contribut Nepalese Stud 20(2):183–196Google Scholar
  100. Manandhar NP (2002) Plants and people of Nepal. Timber Press, Oregon, USAGoogle Scholar
  101. Marasini R, Joshi S (2012) Antibacterial and antifungal activity of medicinal orchids growing in Nepal. J Nep Chem Soc 29:104–109CrossRefGoogle Scholar
  102. Maridassa M, Zahir Hussain MI, Raju G (2008) Phytochemical survey of orchids in the Tirunelveli hills of South India. Ethnobot Leaflets 12:705–712Google Scholar
  103. Marjoka A, Alam O, Huda MK (2016) Phytochemical screening of three medicinally important epiphytic orchids of Bangladesh. J Biol Sci 5(1):95–99Google Scholar
  104. Matsuda H, Morikawa T, Xie H et al (2004) Antiallergic phenanthrenes and stilbenes from the tubers of Gymnadenia conopsea. Planta Med 70(9):847–855PubMedCrossRefPubMedCentralGoogle Scholar
  105. Medhi RP, Chakrabarty S (2009) Traditional knowledge of NE people on conservation of wild orchids. Indian J Tradit Knowl 8(1):11–16Google Scholar
  106. Mikage M, Komastsu K, Takano A et al (1988) A list of Tibetan crude drugs stored in the museum of materia medica research institute for Wakan-Yaku, Toyama medical and pharmaceutical university. In: Namba T (ed) Tibetan medicine and materia medica. Res Inst Wakan-Yaku, Toyama Med Pharma Uni, pp 89–106Google Scholar
  107. Mishra AP, Saklani S (2012) Satyrium nepalense: a rare medicinal orchid of western Himalaya (India); phytochemical screening, antimicrobial evaluation and conservation studies. Indonesian J Pharm 23(3):162–170Google Scholar
  108. Mishra AP, Saklani S, Parcha V et al (2014) A developed and validated high performance thin-layer chromatographic method for the quantitative determination of quercetin in Satyrium nepalense tubers. J Planar Chromatogr 6:444–448CrossRefGoogle Scholar
  109. Mitra A, Sur TK, Upadhyay S et al (2017) Effect of Swarna Jibanti (Coelogyne cristata L.) in alleviation of chronic fatigue syndrome in aged Wistar rats. J Ayurveda Integr Med 9(4):266–271. Scholar
  110. Miyazawa M, Shimamura H, Nakamura SI et al (1997) Antimutagenic activity of gigantol from Dendrobium nobile. J Agric Food Chem 45(8):2849–2853CrossRefGoogle Scholar
  111. Miyazawa M, Shimamura H, Nakamura et al (1999) Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. J Agric Food Chem 47:2163–2167PubMedCrossRefPubMedCentralGoogle Scholar
  112. Moerman D (1998) Native American ethnobotany. Timber Press, OregonGoogle Scholar
  113. Molvray M (1988) Tibetan medicine: a glossary for the study of Tibetan medicinal plants. Series 11. Library of Tibetan Works and Archives. CBT, New Delhi, IndiaGoogle Scholar
  114. Morningstar A (1994) The Ayurvedic cookbook. Motilal Banarsidass Publishers, DelhiGoogle Scholar
  115. Nayak BS, Suresh R, Rao AV et al (2005) Evaluation of wound healing activity of Vanda roxburghii R. Br. (Orchidaceae): a preclinical study in a rat model. Int J Low Extrem Wounds 4(4):200–204PubMedCrossRefPubMedCentralGoogle Scholar
  116. Nguyen VD, Nhu D (1989) Medicinal plants in Vietnam. WHO, GenevaGoogle Scholar
  117. Panda AK, Mandal D (2013) The folklore medicinal orchids of Sikkim. Anc Sci Life 33(2):92–96PubMedPubMedCentralGoogle Scholar
  118. Pant B (2013) Medicinal orchids and their uses: tissue culture a potential alternative for conservation. African J Plant Sci 7(10):448–467CrossRefGoogle Scholar
  119. Pant B (2015) Our orchid conservation effort in two community forests of Central Nepal. In: Orchid Conservation News: The Newsletter of the Orchid Specialist Group of the IUCN SSCGoogle Scholar
  120. Pant B, Raskoti BB (2013) Medicinal orchids of Nepal. Himalayan Map House, Kathmandu, NepalGoogle Scholar
  121. Pant B, Thapa D (2012) In vitro mass propagation of an epiphytic orchid, Dendrobium primulinum Lindl. through shoot tip culture. African J Biotech 11(42):9970–9974Google Scholar
  122. Parmar G, Acharya R (2016) In vitro seed germination of endangered Nepalese orchid species: Dendrobium fimbriatum Hook. Adv J Seed Sci Tech 3(1):72–74Google Scholar
  123. Paudel MR, Pant B (2017) Cytotoxic activity of crude extracts of Dendrobium amoenum and detection of bioactive compounds by GC-MS. Botan Orient: J Plant Sci 11:38–42CrossRefGoogle Scholar
  124. Paudel R, Upadhyaya T, Pahari DP (2012) People’s perspective on access to health care services in a rural district of Nepal. J Nep Med Assoc 52(1):20–24Google Scholar
  125. Paudel MR, Chand MB, Karki N et al (2015) Antioxidant activity and total phenolic and flavonoid contents of Dendrobium amoenum Wall. ex Lindl. Botan Orient 9:20–26CrossRefGoogle Scholar
  126. Paul P, Chowdhury A, Nath D et al (2013) Antimicrobial efficacy of orchid extracts as potential inhibitors of antibiotic resistant strains of Escherichia coli. Asian J Pharma Clin Res 6(3):108–111Google Scholar
  127. Pohle P (1990) Useful plants of Manag district. A contribution to the ethnobotany of Nepal Himalaya. Franzsteiner Verlag, StuttgartGoogle Scholar
  128. Prasad DN, Achari G (1966) A study of anti-arthritic action of Vanda roxburghii in albino rats. J Indian Med Assoc 46(5):234–237PubMedPubMedCentralGoogle Scholar
  129. Prasad R, Koch B (2014) Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study. Biomed Res Int 2014:753451PubMedPubMedCentralGoogle Scholar
  130. Prasad R, Koch B (2016) In vitro anticancer activities of ethanolic extracts of Dendrobium crepidatum and Dendrobium chrysanthum against T-cell lymphoma. J Cytol Histol 7:4. Scholar
  131. Pyakurel D, Gurung K (2008) Enumeration of orchids and estimation of current stock of traded orchids in Rolpa district: final report. DFO Rolpa, Rolpa, NepalGoogle Scholar
  132. Rajbhandary KR (2015) A handbook of the orchids of Nepal. DPR, Kathmandu, NepalGoogle Scholar
  133. Ramesh T, Renganathan P (2016) Study on antimicrobial, anti-inflammatory, antitumor activity of some medicinal orchids- a review. Intl J Res Instinct 3(2):161–169Google Scholar
  134. Rao RSK (1985) Encyclopaedia of Indian medicine: historical perspective, Vol. 1. Popular Prakashan, New DelhiGoogle Scholar
  135. Rashmi K, Shweta SD, Sudeshna CS et al (2015) Antibacterial and radical scavenging activity of selected orchids of Karnataka, India. Sci Tech Arts Res J 4(1):160–164CrossRefGoogle Scholar
  136. Raskoti BB (2009) The orchids of Nepal quality printers Kathmandu, NepalGoogle Scholar
  137. Rokaya MB, Raskoti BB, Timsina B et al (2013a) An annotated checklist of the orchids of Nepal. Nor J Bot 31(5):511–550CrossRefGoogle Scholar
  138. Rokaya MB, Uprety Y, Paudel RC et al (2013b) Traditional uses of medicinal plants in gastrointestinal disorders in Nepal. J Ethnopharmacol 158:221–229CrossRefGoogle Scholar
  139. Roy AR, Patel RS, Patel VS et al (2007) Medicinal orchids of Meghalaya. J Orchid Soc India 21:15–17Google Scholar
  140. Sachdev K, Kulshreshtha DK (1986) Phenolic constituents of Coelogyne ovalis. Phytochemistry 25(2):499–502. Scholar
  141. Saklani A, Jain SK (1994) Cross-cultural ethnobotany of Northeast India. Deep Publications, New DelhiGoogle Scholar
  142. Shakya LR, Bajracharya DM, Chettri MK (1994) Conserving the threatened orchids of Kathmandu Valley. Report Series 8. WWF Nepal Program, Kathmandu, NepalGoogle Scholar
  143. Shanavaskhan AE, Sivadasan M, Alfarhan AH et al (2012) Ethnomedicinal aspects of angiospermic epiphytes and parasites of Kerala, India. Indian J Tradit Knowl 11(2):250–258Google Scholar
  144. Shapoo GA, Kaloo ZA, Ganie AH et al (2013) Ethnobotanical survey and documentation of some orchid species of Kashmir Himalaya, J&K-India. Intl J Pharma Biol Res 4(2):32–42Google Scholar
  145. Shimura H, Matsuura M, Takada N et al (2007) An antifungal compound involved in symbiotic germination of Cypripedium macranthos var. rebunense (Orchidaceae). Phytochemistry 68:1442–1447PubMedCrossRefPubMedCentralGoogle Scholar
  146. Shriram V, Kumar V, Kavi Kishor PB et al (2010) Cytotoxic activity of 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda against human cancer cells. J Ethnopharmacol 128(1):251–253PubMedCrossRefPubMedCentralGoogle Scholar
  147. Shweta SD, Sudeshna CS, Rashmi K et al (2015) Antifungal efficacy of some epiphytic orchids of Karnataka, India. Scholars J Agric Vet Sci 2(3B):266–269Google Scholar
  148. Singh DK (2001) Morphological diversity of the orchids of Orissa. In: Pathak P, Sehgal RN, Shekhar N et al (eds) Orchids: science and commerce. BSMPS, New Delhi, IndiaGoogle Scholar
  149. Singh AP (2006a) Dhanwantri Nighantu. Chaukhambha Orientalia, New DelhiGoogle Scholar
  150. Singh AP (2006b) Raj Nighantu. Chaukhambha Orientalia, New DelhiGoogle Scholar
  151. Singh A, Duggal S (2009) Medicinal orchids-an overview. Ethnobot Leaf 1:13Google Scholar
  152. Singh AP, Sandhu AS (2005) A dictionary of medicinal plants. Singhal, S. Sundeep Publishers, New DelhiGoogle Scholar
  153. Singh DR, Kishore R, Kumar R et al (2016) Orchid preparations: Tech bull 00. ICAR, Nat Res Center for Orchids, SikkimGoogle Scholar
  154. Subedi A (2002) Orchids around Pokhara valley of Nepal. LI-BIRD occasional paper no. 1. Pokhara, NepalGoogle Scholar
  155. Subedi A, Subedi N, Chaudhary RP (2007) Panchase Forest: an extraordinary place for wild orchids in Nepal. Pleoine 1:23–31Google Scholar
  156. Subedi A, Kunwar B, Choi Y et al (2013) Collection and trade of wild-harvested orchids in Nepal. J Ethnobiol Ethnomed 9:64PubMedPubMedCentralCrossRefGoogle Scholar
  157. Sutton S (1978) Plant collectors in Nepal. In: Hara H (ed) An enumeration of the flowering plants of Nepal, vol 1. Trustees of the British Museum (Natural History), London, pp 13–21Google Scholar
  158. Teja J, Naroop PD, Sumanth N et al (2012) Anti-diarrhoeal activity of petroleum ether extract of Vanda tessellata leaves on castor oil induced diarrhea in rats. Int J Phytopharm Res 3(2):99–102Google Scholar
  159. Teoh ES (2016) Medicinal orchids of Asia. Springer, SwitzerlandCrossRefGoogle Scholar
  160. Tezuka Y, Ji L, Hirano H et al (1990) Studies on the constituents of orchidaceous plants IX constituents of Spiranthes sinensis (Pers.) Ames var. amoena (M. Bieberson [M. Bieberstein]) Hara.(2): structures of spiranthesol, spiranthoquinone, spiranthol-C and spiransineol-B, new isopentenyldihydrophenanthrenes. Chem Pharm Bull 38:629–635CrossRefGoogle Scholar
  161. Thakur M, Dixit VK (2007) Aphrodisiac activity of Dactylorhiza hatagirea (D. Don) Soo in male albino rats. Evidence-Based Compl Alter Med 4:29–31CrossRefGoogle Scholar
  162. Thakur RB, Yadav RP, Thakur NP (2010) Enumerating the status of orchid species of Makawanpur district. Hamro Kalpabricha 20:1–18Google Scholar
  163. Thapa L (2009) The research project on edible wild plants of Bhutan and their associated traditional knowledge. J Fac Agric Shinshu Uni 45(1):43–48Google Scholar
  164. Tiwari AP, Joshi B, Ansari AA (2012) Less known ethnomedicinal uses of some orchids by the tribal inhabitants of Amarkantak Plateau, Madhya Pradesh. India Nat Sci 10(12):33–37Google Scholar
  165. Vaidya BD (1991) Materia Medica of Ayurveda, Based on Madanpala’s Nighantu. Jain Publishers, New Delhi, IndiaGoogle Scholar
  166. Vaidya BN, Shrestha M, Joshee N (2002) Report on Nepalese orchids species with medicinal properties. In: Watanabe T, Takano A, Bista MS, Saiju HK (ed) Proceedings of Nepal-Japan joint symposium on conservation and utilization of Himalayan medicinal resources, KathmanduGoogle Scholar
  167. Venkateswarlu S, Satyanarayana B, Sureshbabu CV et al (2003) Synthesis and antioxidant activity of 4-[2-(3,5-Dimethoxyphenyl)ethenyl]-1,2-benzenediol, a metabolite of Sphaerophysa salsula. Biosci Biotechnol Biochem 67(11):2463–2466PubMedCrossRefPubMedCentralGoogle Scholar
  168. Wang Y, Guan SH, Meng YH et al (2013) Phenanthrenes, 9,10-dihydrophenanthrenes, bibenzyls with their derivatives, and malate or tartrate benzyl ester glucosides from tubers of Cremastra appendiculata. Phytochemistry 94:268–276PubMedCrossRefPubMedCentralGoogle Scholar
  169. Wang X, Chen X, Yang P et al (2017) Barcoding the Dendrobium (Orchidaceae) species and analysis of the intragenomic variation based on the internal transcribed spacer. Biomed Res Int 2:1–10Google Scholar
  170. Watanabe T, Rajbhandari KR, Malla KJ et al (2005) A handbook of medicinal plants of Nepal. Kobfai Publishing Project, BangkokGoogle Scholar
  171. WECS (2013) Energy sector synopsis report Nepal-2013. Water and Energy Commission Secretariat, KathmanduGoogle Scholar
  172. Wilson MF (2007) Medicinal plant fact sheet: Cypripedium: Lady’s slipper orchids. A collaboration of the IUCN medicinal plant specialist group, PCA-medicinal plant working group, and North American pollinator protection campaign, Arlington, VirginiaGoogle Scholar
  173. Xia WB, Xue Z, Li S et al (2005) Chemical constituents from tuber of Cremastra appendiculata. Zhongguo Zhong Yao Za Zhi 30:1827–1830PubMedPubMedCentralGoogle Scholar
  174. Xu J, Yu H, Qing C et al (2009) Two new biphenanthrenes with cytotoxic activity from Bulbophyllum odoratissimum. Fitoterapia 80(7):381–384PubMedCrossRefPubMedCentralGoogle Scholar
  175. Xue Z, Li S, Wang S et al (2006) Mono-, Bi-, and Triphenanthrenes from the tubers of Cremastra appendiculata. J Nat Prod 69(6):907–913. Scholar
  176. Yamaki M, Honda C (1996) The stilbenoids from Dendrobium plicatile. Phytochemistry 43(1):207–208. Scholar
  177. Yan L, Chun-Lan W, Shun-Xing G et al (2008) Four new bibenzyl derivatives from Dendrobium candidum. Chem Pharm Bull 56:1477–1479CrossRefGoogle Scholar
  178. Yang L, Qin LH, Bligh SW et al (2006) A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities. Bioorg Med Chem 14:3496–3501PubMedCrossRefPubMedCentralGoogle Scholar
  179. Yang SY, Wang SG, Li HL et al (2013) Research status of identification on CAULIS DENDROBII. J Anhui Agric Sci 41:1495–1497Google Scholar
  180. Yonzone R, Lama D, Bhujel RB et al (2012a) Terrestrial and semi saprophytic orchid species diversity of Darjeeling Himalaya of West Bengal, India. McAllen Int Orchid Soc J 13(4):2–20Google Scholar
  181. Yonzone R, Kamran A, Bhujel RB (2012b) Orchids in ethnobotany. Proceeding, volume, Int. Sem on multidis. Appr Angiosp. System 2:661–669Google Scholar
  182. You HL, Park JD, Baek NI et al (1995) In vitro and in vivo antimural phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med 61:178–180CrossRefGoogle Scholar
  183. Yu S, Wang Z, Su Z et al (2018) Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med 18:59PubMedPubMedCentralCrossRefGoogle Scholar
  184. Zha XQ, Luo JP, Wei P (2009) Identification and classification of Dendrobium candidum species by fingerprint technology with capillary electrophoresis. SA J Bot 75:276–282CrossRefGoogle Scholar
  185. Zhan HD, Zhou HY, Sui YP et al (2016) The rhizome of Gastrodia elata Blume An ethnopharmacological review. J Ethnopharmacol 189:361–385PubMedCrossRefPubMedCentralGoogle Scholar
  186. Zhang JH, Guo SX, Yang JS (1999) Studies on chemical constituents of the fungus accelerating the growth of Anoectochilus roxburghii. Chin Pharm J 34:800–802. (in Chinese with an English abstract)Google Scholar
  187. Zhao W, Ye Q, Tan X et al (2001) Three new sesquiterpene glycosides from Dendrobium nobile with immunomodulatory activity. J Nat Prod 64:1196–2000PubMedCrossRefPubMedCentralGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Agricultural Research Station, College of Agriculture, Family Sciences and TechnologyFort Valley State UniversityFort ValleyUSA

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