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The Evolution of Transfusion Therapy in Trauma

  • Colin H. Murphy
  • John B. Holcomb
  • John R. HessEmail author
Chapter
  • 36 Downloads

Abstract

Transfusion has played a critical role in the history and development of trauma care since the first blood bank was established 100 years ago. Rapid access to a full range of blood products saves lives. Initial treatment of massive hemorrhage is formulaic, attempting to replace lost blood volume, oxygen carrying capacity, and hemostatic activity simultaneously. This can be accomplished with whole blood, but components are currently more widely available and appear to be satisfactory when used in balanced ratios. Laboratory-guided resuscitation should be initiated when bleeding slows and is possible with viscoelastic testing or conventional laboratory tests.

Keywords

Injury Trauma Hemorrhage Coagulopathy Acute coagulopathy of trauma Trauma-induced coagulopathy Transfusion Massive transfusion Resuscitation Hemostatic resuscitation Damage control resuscitation Balanced resuscitation 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Colin H. Murphy
    • 1
  • John B. Holcomb
    • 2
  • John R. Hess
    • 3
    Email author
  1. 1.Department of PathologyUniversity of Maryland Medical CenterBaltimoreUSA
  2. 2.Department of Surgery, University of Alabama at BirminghamBirminghamUSA
  3. 3.Department of Laboratory Medicine, University of Washington School of MedicineSeattleUSA

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