Malignant Tumours of the Male Reproductive System

  • Fabrizio GiannandreaEmail author


Testicular cancer and prostate cancer represent the most commonly occurring tumours of the male reproductive system. Hormonal, racial, and epidemiological characteristics of these two tumours appear somehow specular and reverse. Prostate cancer is commonly diagnosed among the elderly and rare among younger men and, by contrast, testicular cancer is very frequent among young men and uncommon in older ages. The highest incidence of prostate cancer is recorded among native African populations, while contextually Africans register the lowest incidence for testicular cancer. Recent epidemiologic studies have suggested that exposure to androgens could be partly implicated in lowering the risk of testicular cancer. In contrast, androgens and androgen receptor polymorphism were suggested to promote prostate carcinogenesis.

With regard to occupations, firefighting, long-term use of pesticides, and exposure to specific organochlorine compounds as well, are likely to be associated with testicular cancer. Exposure to pesticides is the main occupational risk factor of interest also for prostate cancer although the evidence of such an association is still argued. This chapter aims to discuss the current scientific research on prostate cancer and testicular cancer with regard to their modifiable and non-modifiable risk factors, and with a special focus on the role of pesticides and other environmental exposures with endocrine-disrupting activity acting in cancer development of both these tumours.


Testicular cancer Prostate cancer Occupation Pesticide Endocrine disruptors 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Occupational Health Unit, Local Health Authority, ASL 2 AbruzzoS.S. Annunziata University HospitalChietiItaly

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