Fungal Polyketides: Chemical Diversity and Their Cytotoxic Effects
Compounds isolated from different natural sources have over the years played crucial roles in the treatment of a wide range of human diseases. Over the past six decades, microorganisms have provided valuable active compounds for the treatment of various diseases. Fungi, in general, produce diverse structural classes of natural products including polyketides, a major class of secondary metabolites obtained from various natural sources‚ which as a group have interesting chemical diversity. In addition, polyketides are known to possess a number of biological and pharmacological effects, viz. cytotoxic, antibacterial, antifungal, antiparasitic, and immunosuppressive effects. In this chapter the focus is on describing the cytotoxic effects of polyketides isolated from fungi and in particular their potential as cancerostatic pharmaceuticals.
KeywordsPolyketides Fungi Cytotoxicity Chemcial diversity
The author (HH) thanks the Alexander von Humboldt Foundation for its generous support in providing the opportunity to do work in Germany, which facilitated the writing of this review. The authors want to thank Dr. Abdullah M. Al-Sadi who helped with comments and criticism by reading the manuscript.
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