Central Venous Catheters and Biofilm Infections
Central venous catheter (CVC) use has become commonplace. Infections that have plagued mankind for centuries continue to challenge medical devices, both those that are old and those that are integrated into healthcare systems. Bacterial biofilms consist of microorganisms that create an environment with multiple characteristics including a slimy matrix and varying cell types. As these communities adhere to catheter surfaces, they can cause bloodstream infections. These are problems that surgeons and healthcare workers deal with on a daily basis. We need unique and effective therapies that can be integrated with CVC devices that will eradicate biofilms, reduce patient suffering, and improve our ability to deliver necessary medications with reduced complications.
KeywordsCentral venous catheter Biofilm Characteristics Infection Antimicrobial strategies
The opinions and assertions included in this chapter are those of the author and do not reflect BD or affiliates.
- 1.Massengill, S. E. (1943). A sketch of medicine and pharmacy and a view of its progress by the Massengill family from the fifteenth to the twentieth century. SE Massengill: Bristol.Google Scholar
- 3.Borgognnoni, T. (1955). The surgery of Theodoric: ca AD 1267. Campbell E, Colton J, translators. New York: Appleton Century Crofts.Google Scholar
- 4.Duncan, L. C. (1931). Medical men in the American revolution, 1775e1783. Carlisle: Medical Field Service School.Google Scholar
- 5.https://www.cdc.gov/washington/~cdcatWork/pdf/infections.pdf. Accessed on 1/5/2019.
- 11.O’Grady, N. P. et al. CDC guidelines for the prevention of intravascular catheter related infections. (2011)Google Scholar
- 12.Ash, A., et al. (2016). Seldinger Technique for placement of “peripheral” IJ lines. Western Journal of Emergency Medicine.Google Scholar
- 13.Haddadin, Y., & Regunath, H. (2018). Central Line Associated Blood Stream Infections (CLABSI) [Updated 2018 Oct 27]. In StatPearls [Internet]. Treasure Island: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/pubmed/28613641.
- 14.Bowdle, A. et al, Arterial cannulation during central line placement. Mirador Biomedical Report, (2009).Google Scholar
- 15.Millennium Research Group. US Markets for Vascular Access Devices. (2011).Google Scholar
- 16.Ezaru, C., et al. (2009). Eliminating arterial injury during central venous catheterization using manometry. IARS Journal, 109(1), 130–134.Google Scholar
- 20.Services, D. O. (2013). Action plan to prevent health care-associated Infections: Road map to elimination. Retrieved from hhs.gov
- 21.Agency for Healthcare Research and Quality. (2011). Eliminating CLABSI A National Imperative. AHRQ, 1–29.Google Scholar
- 22.CDC guidelines. (2011).Google Scholar