Translation of Antibiofilm Technologies to Wounds and Other Clinical Care

  • Matthew MynttiEmail author


Nearly 80% of global bacterial infections are associated with biofilm bacteria (Joo, Otto, Chem Biol 19:1503–1513, 2012). In contrast to planktonic bacteria, biofilms are a complex, organized bacterial community possessing a sophisticated protective armor, in the form of the extracellular polymeric substance (EPS), which acts as a robust defense mechanism against eradication. Chronic biofilm infections affect 17 million people annually, and approximately 550,000 people die as a result of their chronic infections (Wolcott et al J Wound Care 19:45–50, 2010). The challenge with biofilm-related infections is that they cannot be adequately confirmed via diagnostic tests in the clinical setting, and, more importantly, they are intrinsically resistant to host immunity, antibiotics, and biocides. This renders current therapeutic options inadequate to successfully eradicate the infection. Next Science™ has applied novel material science methods to combat biofilm through its innovative Xbio™ technology. Xbio technology, which includes the proprietary product, BlastX™, works by disrupting the biofilm matrix and creating an environment that compromises the biofilm’s structural integrity. In doing so, the EPS can be broken down and removed, thereby allowing the pathogens within the environment to be targeted and preventing the biofilm’s reformation.


Wound Biofilm Infection BlastX Topical Healing 



Dr. Myntti has financial interest in Next Science and the technologies discussed.


  1. 1.
    Joo, H. S., & Otto, M. (2012). Molecular basis of in-vivo biofilm formation by bacterial. Chemistry & Biology, 19(12), 1503–1513.CrossRefGoogle Scholar
  2. 2.
    Wolcott, R., Rhoads, D., Bennett, M., Wolcott, B., Gogokhia, L., Costerton, J., & Dowd, S. (2010). Chronic wounds and the medical biofilm paradigm. Journal of Wound Care, 19(2), p45–p50.CrossRefGoogle Scholar
  3. 3.
    Landén, N. X., & Li, D. (2016). Mona Ståhle.Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences, 73(20), 3861–3885.CrossRefGoogle Scholar
  4. 4.
    Attinger, C., & Wolcott, R. (2012). Clinically addressing biofilm in chronic wounds. Advances in Wound Care, 1(3), 127–132.CrossRefGoogle Scholar
  5. 5.
    Aziz-Abdel, M. S. (2014). Bacterial biofilm: Dispersal and inhibition strategies. SAJ Biotechnology, 1, 105. Scholar
  6. 6.
    Frykberg, R. G., & Banks, J. (2015). Challenges in the Treatment of Chronic Wounds. Advances in Wound Care, 4(9), 560–582. Scholar
  7. 7.
    Flemming, H. C., & Wingender, J. (2010). The Biofilm Matrix. Nature Reviews Microbiology, 8, 623–633.Google Scholar
  8. 8.
    Performance of the Massachusetts Health Care System Series: A focus on provider quality. CHIA Center for Health Information and Analysis,
  9. 9.
    Bjarnsholt, T., Kirketerp-Møller, K., Jensen, P. Ø., et al. (2008). Why chronic wounds will not heal: a novel hypothesis. Wound Repair and Regeneration, 16(10), 2–10.CrossRefGoogle Scholar
  10. 10.
    Sen, C., Gordillo, G., Roy, S., Kirsner, R., Lambert, L., Hunt, T., Gottrup, F., Gurtner, G., & Longaker, M. (2009). Human skin wounds: A major and snowballing threat to public health and economy. Wound Repair and Regeneration, 17(6), 763–771.CrossRefGoogle Scholar
  11. 11.
    Hall-Stoodley, L., & Stoodley, P. (2009). Evolving concepts in biofilm infections. Cell Microbiol, 11(7), 1034–1043.CrossRefGoogle Scholar
  12. 12.
    Brooun, A., Liu, S., & Lewis, K. (2000). A dose response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 44(3), 640–646.CrossRefGoogle Scholar
  13. 13.
    Lewis, K. (2007). Persister cells, dormancy and infectious disease. Nature Reviews. Microbiology, 5(1), 48–56.31.CrossRefGoogle Scholar
  14. 14.
    Davies, D. G., Parsek, M. R., Pearson, J. P., et al. (1998). The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science, 280(5361), 295–298.CrossRefGoogle Scholar
  15. 15.
    Carroll, K., Hobden, J., Miller, S., Morse, S., Mietzner, T., Detrick, B., Mitchell, T., McKerrow, J., & Sakanari, J. (2016). Jawetz, Melnick, & Adelbergs medical microbiology (27th ed.). Shenzen: McGraw-Hill.Google Scholar
  16. 16.
    Kim et al. (2018). Wounds, 30(5), 114–119. Epub 2018 February 23 (Biofilms Made Easy (wounds international) – Phillips; Skin and Wound Care 2013 – Kevin Wu; Wound Education Update Feb 2014 – Wounds UK Best Practice Statement)Google Scholar
  17. 17.
    Snyder, R. J., Bohn, G., Hanft, J., Harkless, L., Kim, P., Lavery, L., Schultz, G., & Wolcott, R. (2017). Wound bioflm: current perspectives and strategies on biofilm disruption and treatments. Wounds, 29(6), S1–S17.PubMedGoogle Scholar
  18. 18.
    Snyder, R. J., Bohn, G., Hanft, J., Harkless, L., Kim, P., Lavery, L., Schultz, G., & Wolcott, R. (2017). Wound Biofilm: Current Perspectives and Strategies on Biofilm Disruption and Treatments. Wounds, 29(6), S1–S17.PubMedGoogle Scholar
  19. 19.
    Ryder, M. (2005). Catheter related infections – It’s all about biofilms. Topics in Advanced Practice Nursing eJournal, 5(3), 1–6.Google Scholar
  20. 20.
    Data on file. Center for Biofilm Engineering at Montana State University. Next Science Report TR-10-12-004.Google Scholar
  21. 21.
    Mallefet, P., & Dweck, A. C. (2008). Mechanisms involved in wound healing. Biomedical Scientist, 52(7), 609.Google Scholar
  22. 22.
    Next Science website.
  23. 23.
  24. 24.
  25. 25.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Next Science®SydneyAustralia

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