Role of Infiltrating Microglia/Macrophages in Glioma

  • Myriam Catalano
  • Giuseppina D’Alessandro
  • Flavia Trettel
  • Cristina LimatolaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1202)


In this chapter we describe the state of the art knowledge of the role played by myeloid cells in promoting and supporting the growth and the invasive properties of a deadly brain tumor, glioblastoma. We provide a review of the works describing the intercellular communication among glioma and associated microglia/macrophage cells (GAMs) using in vitro cellular models derived from mice, rats and human patients and in vivo animal models using syngeneic or xenogeneic experimental systems. Special emphasis will be given to 1) the timing alteration of brain microenvironment under the influence of glioma, 2) the bidirectional communication among tumor and GAMs, 3) possible approaches to interfere with or to guide these interactions, with the aim to identify molecular and cellular targets which could revert or delay the vicious cycle that favors tumor biology.


GAMs Innate immunity Brain tumors Glioma Animal models Ion channels 



a disintegrin and metalloproteinase, arg-1, arginase-1


adenosine triphosphate


brain-derived neurotrophic factor


bone marrow


cyclic adenosine monophosphate


cyclic guanosine monophosphate


central nervous system




colony stimulating factor-1


chemokine C-X-C ligand


extracellular matrix


enriched environment


epidermal growth factor


extracellular vesicles


focal adhesion kinase


fragment crystallizable Fc-gamma receptor


fibrinogen-like protein 2


glioma associated microglia/macrophage cells


growth arrest specific 6


glioblastoma multiforme


glial-derived neurotrophic factor


granulocyte/macrophage colony-stimulating factor


glycoprotein non-metastatic melanoma protein B


hepatocyte growth factor/scatter factor


high-mobility group box






interferon regulatory factor


Ca2+-activated K channel


mitogen-activated protein kinase


milk fat globule EGF like factor 8


major histocompatibility complex


matrix metalloproteinase


multiple sclerosis


neuron-glial antigen 2/chondroitin sulfate proteoglycan 4

NK cells

natural killer cells


nitric oxide


programmed cell death protein-1


platelet derived growth factor


protein kinase A


protein kinase G


protein S


reactive oxygen species


Runt-related transcription factor 1


signal regulatory protein α


signal transducer and activator of transcription 2


stress inducible protein 1


transforming growth factor


transglutaminase 2


thymidine kinase


Toll-like receptor




tropomyosin receptor kinase B


vascular endothelial growth factor


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Myriam Catalano
    • 1
  • Giuseppina D’Alessandro
    • 1
    • 2
  • Flavia Trettel
    • 1
  • Cristina Limatola
    • 1
    • 2
    Email author
  1. 1.Department of Physiology and PharmacologySapienza University of RomeRomeItaly
  2. 2.IRCCS NeuromedPozzilliItaly

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