Protein Conformational Changes and Low-Frequency Vibrational Modes: A Similarity Analysis

  • Domenico ScaramozzinoEmail author
  • Giuseppe Lacidogna
  • Alberto Carpinteri
Conference paper
Part of the Conference Proceedings of the Society for Experimental Mechanics Series book series (CPSEMS)


The study of protein vibration and dynamics is receiving increasing attention among researchers, both from a numerical and experimental perspective. By using terahertz spectroscopy techniques, it has been shown that conformational changes, crucial for protein biological function, are strictly related to low-frequency vibrational modes. These motions generally occur in the terahertz range (~0.1–2 THz) involving large portions of the protein. The present contribution aims at investigating the role of terahertz (expansion-contraction) vibrational modes to protein conformational change from a numerical viewpoint. Modal analysis is performed by using Cα-only coarse-grained mechanical models: the obtained mode shapes are compared, by means of three similarity indexes, to the displacement field of protein conformational change. In particular, lysine-arginine-ornithine (LAO) binding protein is selected as a case study.


Conformational change THz vibrational modes Modal analysis Similarity indexes LAO binding protein 


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Copyright information

© Society for Experimental Mechanics, Inc. 2020

Authors and Affiliations

  • Domenico Scaramozzino
    • 1
    Email author
  • Giuseppe Lacidogna
    • 1
  • Alberto Carpinteri
    • 1
  1. 1.Politecnico di Torino, Department of Structural, Geotechnical and Building EngineeringTorinoItaly

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