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Nanoparticles in Nanotheranostics Applications

  • Nadun H. Madanayake
  • Ryan Rienzie
  • Nadeesh M. AdassooriyaEmail author
Chapter

Abstract

Nanotheranostics, the amalgamation of diagnosis and therapeutic functions with nanotechnology, is a novel approach in personalized medicine. The advancement of nanotechnology offers a greater opportunity to engineer nanoparticles in theranostics applications and it has shown promising results especially in cancer therapy compared to conventional treatments. Since nanoparticles possess enhanced surface properties, they are capable of orienting nanotheranostic agents in specific sites of disease through which it significantly reduces the undesired side effects. In addition, the biocompatibility of those nanotheranostic agents with target cells or tissues provides a greater advantage to apply them in therapeutic functions as well as in imaging. Primarily metallic, magnetic, polymeric nanoparticles and quantum dots are used in nanotheranostics applications and gold-based nanomaterials and superparamagnetic iron oxide nanoparticles have attracted significant attention in recent years. Therefore, the aim of this chapter is to discuss the use of nanoparticles in theranostic applications while made them functionally important in nanotheranostics for personalized medicine.

Keywords

Nanoparticles Nanotheranostics Personalized medicine Therapeutics Cancer treatments 

Nomenclature

CT

Computed tomography imaging

DNA

Deoxyribonucleic acid

EPR

Enhanced permeability and retention

FA

Folic acid

Gd2O3-AuNCs

gadolinium oxide–gold nanoclusters

IONPs

Iron oxide nanoparticles

MPNs

Magnetic nanoparticles

MRI

Magnetic resonance imaging

NIR

Near infrared

NPs

Nanoparticles

PA

Photoacoustic imaging

PDT

Photodynamic therapy

PEG

Polyethylene glycol

PET

Positron emission tomography

PL

Photoluminescence

PS

Photosensitizers

PTT

Photothermal therapy

PTX

Paclitaxel

ROS

Reactive oxygen species

RT

Radiotherapy

SERS

Surface-enhanced Raman spectroscopy

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nadun H. Madanayake
    • 1
  • Ryan Rienzie
    • 2
  • Nadeesh M. Adassooriya
    • 3
    Email author
  1. 1.Department of BotanyUniversity of Sri JayewardenepuraNugegodaSri Lanka
  2. 2.Faculty of AgricultureUniversity of PeradeniyaPeradeniyaSri Lanka
  3. 3.Department of Food Science & TechnologyWayamba University of Sri LankaMakanduraSri Lanka

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