Theranostic Applications of Nanobiotechnology in Cancer
Cancer is a devastating disease and leading cause of death worldwide. Although many furtherance has been made regarding conventional diagnosis and treatment of cancerous tumors, still many gaps remain to be filled in overcoming this menace. Many benchmarks have been achieved regarding clinical translation with special emphasis on implementation of nanotheranostics in healthcare sector. This has led to mitigation in nanoparticles toxicity and patient’s resistance to drugs. Nanotheranostics has remarkable applications in patient stratification, treatment of cancer stem cells (CSCs) and drug-resistant cancer. Novel strategies including synthesis and engineering of different nanoparticles have been developed that fulfill the purpose of early diagnosis and specified drug delivery to target site. Multifunctional nanoformulations have also been made to perform diagnosis, targeting, and treatment simultaneously. This chapter describes the biology of cancer and concept of nanobiotechnology and nanomedicine for various biomedical applications, having particular emphasis on cancer remedy via nanotheranostics. The advances in nanotheranostics have been discussed in detail and the ways to overcome respective challenges to this technology have been narrated.
KeywordsCancer Nanoparticles Targeted drug delivery Nanotheranostics Nano-oncology
- AbdElhamid AS, Helmy MW, Ebrahim SM, Bahey-El-Din M, Zayed DG, Zein El Dein EA, El-Gizawy SA, Elzoghby AO. Layer-by-layer gelatin/chondroitin quantum dots-based nanotheranostics: combined rapamycin/celecoxib delivery and cancer imaging. Nanomedicine. 2018;13(10). https://doi.org/10.2217/nnm-2018-0028.
- Chen H, Zhang W, Zhu G, Xie J, Chen X. Rethinking cancer nanotheranostics. Nat Rev Mater. 2017;2. https://doi.org/10.1038/natrevmats.2017.2.
- Granada-Ramirez DA, Arias-Ceron JS, Rodriguez-Fragoso P, Vazquez-Hernandez F, Luna-Arias JP, Herrera-Perez JL, Mendoza-Alvarez JG. Quantum dots for biomedical applications. In: Narayan R, editor. Nanobiomaterials. Sawston: Woodhead Publishing; 2018. p. 411–36. https://doi.org/10.1016/B978-0-08-100716-7.00016-7.CrossRefGoogle Scholar
- Jiang W, von Roemeling CA, Chen Y, Qie Y, Liu X, Chen J, Kim YS. Designing nanomedicine for immuno-oncology. Nat Biomed Eng. 2017b;1(2). https://doi.org/10.1038/s41551-017-0029.
- Kievit FM, Zhang M. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Adv Mater. 2011;20:1–31.Google Scholar
- Patel SP, Patel PB, Parekh BB. Application of nanotechnology in cancer prevention, early detection and treatment. J Cancer Res Therap. 2014;10(3):479–86.Google Scholar
- Satpathy M, Wang L, Zielinski RJ, Qian W, Wang YA, Mohs AM, Kairdolf BA, Ji X, Capala J, Lipowska M, Nie S, Mao H, Yang L. Targeted drug delivery and image-guided therapy of heterogeneous ovarian cancer using Her2-targeted theranostic nanoparticles. Theranostics. 2019;9(3):778–95.PubMedPubMedCentralCrossRefGoogle Scholar
- Sisay B, Abrha S, Yilma Z, Assen A, Molla F, Tadese E, Wondimu A, Gebre-Samuel N, Pattnaik G. Cancer nanotheranostics: a new paradigm of simultaneous diagnosis and therapy. J Drug Deliv Therap. 2014;4(5):79–86.Google Scholar
- Wang L-S, Chuang M-C, Ho JA. Nanotheranostics—a review of recent publications. Int J Nanomed. 2012;7:4679–95.Google Scholar
- Zare-Zardini H, Amiri A, Shanbedi M, Taheri-Kafrani A, Sadri Z, Ghanizadeh F, Neamatzadeh H, Sheikhpour R, Boroujeni FK, Dehshiri RM, Hashemi A, Aminorroaya MM, Dehgahnzadeh MR, Shahriari SH. Nanotechnology and pediatric cancer: prevention, diagnosis and treatment. Iranian J Pediat Hematol Oncol. 2015;5(4):233–48.Google Scholar